Proceeding of the Shevchenko Scientific Society. Medical Sciences 2020-08-04T11:46:55+03:00 Oksana Zayachkivska Open Journal Systems Peer-reviewed journal "Proceeding of the Shevchenko Scientific Society. Medical Sciences" published by Shevchenko Scientific Society EDITORIAL 2020-08-04T11:08:16+03:00 Oksana Zayachkivska <p>In the course of four short months, the 2019 novel coronavirus disease (COVID-19) has entered the annals of human history as a pandemic. After its initial identification in the Wuhan region of China in December 2019, it rapidly spread across the globe and by March 2020 had been detected in Ukraine and 110 other countries. On March 11, 2020, the World Health Organization (WHO) officially declared the spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to have reached pandemic levels which constituted an emergency requiring implementation of quarantine measures. The continuing community spread of this originally zoonotic infection is now the most formidable and urgent challenge to the physical, psychological and economic health of humanity. The world did not anticipate the outbreak and rapid spread of COVID-19. By April, 12, 2020 some 1,800,000 persons have been infected and 110,000 have died.</p> <p>Physicians and scientists around the globe are joining forces in the battle against a formidable foe that has already inflicted human, social, and economic losses not seen since World War II. Given the absence of any effective evidence-based treatments, there is a consensus that prevention is of primary importance as we strive to develop an understanding of the short- and long-term consequences of the disease. There has also been landmark recognition that inter-disciplinary scientific research into the pathogenesis and resulting pathophysiology of COVID-19 is critical to the development of improved diagnostic approaches and potentially preventive measures such as immunization, that could help us vanquish the disease.</p> <p>Today, synergistic efforts by the WHO, politicians, leaders, and experts from all spheres of the society life are directed at one common goal – halting the spread of COVID-19 and finding effective measures to counteract the effects of the responsible virus, SARS-CoV-2.</p> <p>The oldest Ukrainian medical journal <em>Proceedings of the Shevchenko Scientific Society: Medical Sciences</em> (<em>Праці Наукового Товариства імені Шевченка. Медичні науки</em>) cannot remain indifferent to the COVID-19 pandemic. An invitation to join a discussion of critically relevant issues in an online webinar “<em>COVID-19 Pandemic. Journal Editorial Policies in the Modern Scientific Space and the Role of Editor Associations</em>” on World Health Day 2020, to be moderated by Olena Zimba, MD, PhD via ZOOM (due to quarantine measures) was answered by almost 100 participants, including members of the editorial board and representatives of numerous Ukrainian institutions. Today’s issue of the <em>Proceedings</em> <em>of the Shevchenko Scientific Society: Medical Sciences</em> provides a report of that conference, with presentations and articles by leading experts in epidemiology, immunology, and infectious diseases from Danylo Halytsky National Medical University in L’viv. These include professors Natalia Vynohrad, Valentyna Chopyak, Oleksandr Zinchuk. Olena Zimba discussed the editorial challenges presented by the current pandemic and underscored the importance of integration of and cooperation between various media platforms and organizations in the modern scientific space.</p> <p>A key weapon in the battle with COVID-19 is the rapid dissemination of knowledge about the signs, symptoms and course of the disease in high risk patients who suddenly find themselves in the unenviable position of having to choose “<em>between Scylla and Charybdis” </em>as described in ancient Greek mythology. This was the highly apposite term that one of our authors and a leader in the field of oncology and cancer chemotherapy Yarolsav Shparyk, adopted in his article on the critical danger posed by the comorbidity of cancer and COVID-19. Our other participant, the scientific team from the microbiology laboratory of Olena Korniyenko, professor at the Danylo Halytsky National Medical University in Lviv, addressed issues in the development of safety measures that would balance the risks to and preserve the dignity of the medical community while they strive to minimize the human toll of the virus. We encourage you to submit additional materials germane to urgent clinical and public health needs posed by the COVID-19 pandemic.</p> 2020-04-14T00:00:00+03:00 Copyright (c) THE 2020 THE SHEVCHENKO SCIENTIFIC SOCIETY MEDICAL COMMISSION CONFERENCE: “COVID-2019. EDITORIAL POLICY OF JOURNALS IN THE MODERN SCIENTIFIC SPACE AND THE ROLE OF EDITORS' ASSOCIATIONS”, APR, 7, 2020, LVIV, UKRAINE 2020-08-04T11:08:33+03:00 Ulyana Telishevska Iryna Stryiska Zoriana Sorochynska <p><a href=""></a></p> <p>The 2020 The Shevchenko Scientific Society Medical Commission Conference: “COVID-2019 Pandemic. Editorial Policy of Journals in the Modern Scientific Space and the Role of Editors' Associations” was carried out as a webinar on April 7, 2020. The event was supported by Danylo Halytsky Lviv National Medical University (Lviv, Ukraine), Shevchenko Scientific Society and Western Scientific Center of the National Academy of Sciences of Ukraine and Ministry of Education and Science of Ukraine.</p> <p>The conference focused on the urgent need to develop strategy of prevention COVID-2019 pandemic and roles of members of scientific community to contribute in global efforts to improve scientific writing and editing. About 100 people attended the webinar. Among them were representatives from Lviv, Odesa, Drohobych, Ivano-Frankivsk, as well as from other countries, from Qatar, USA, UK. The webinar was conducted through the Zoom platform (due to quarantine measures), and participants were able to listen to interesting scientific reports from leading epidemiologists, immunologists and infectious diseases specialists and ask questions on the lecture’s themes.</p> <p>Leading professors of Danylo Halytsky Lviv National Medical University were the speakers of the first part of the webinar dedicated to COVID-2019 pandemic. Natalya Vynograd (Epidemiology Department), covered the epidemiological aspects of the COVID-2019 pandemic, Valentyna Chopyak (Clinical Immunology and Allergology Department), made a report on immunological features of the COVID-2019 pandemic, Olexandr Zinchuk, (Infectious Diseases Department), was covering clinical manifestations, features of diagnostics and treatment COVID-2019.</p> <p>Among the speakers of the second part of the webinar was Armen Yuri Gasparyan, MD, PhD, FESC, member of the World Association of Medical Editors, Associate Professor of Medicine of the University of Birmingham (UK). He reported the requirements for journals, indexed in international scientific databases and the role of Scientific Editors’ Associations in his first lecture and described the standards of peer review of scientific articles in his second lecture. This part of the webinar was English speaking.</p> <p>These lectures were preceded by questions from the participants of the webinar and an active discussion about the prospects of creation of the Ukrainian or Eastern European Council of Science Editors.</p> <p>Oksana Zayachkivska, Physiology Department), Editor-in-Chief of the “Proceeding of the Shevchenko Scientific Society. Medical Sciences” and Roman Kushnir, Academician of National Academy of Sciences of Ukraine, Chairman of the Shevchenko Scientific Society summarized the webinar, emphasizing on inter-disciplinary collaboration and cooperation, and wished everyone good health and prosperity.</p> 2020-04-14T00:00:00+03:00 Copyright (c) LAUNCHING UKRAINIAN COUNCIL OF SCIENCE EDITORS AND EDUCATING REGIONAL JOURNAL EDITORS 2020-08-04T11:08:47+03:00 Olena Zimba Oksana Zayachkivska Valentyna Chopyak <p>Global editorial associations have accumulated knowledge and resources that could be helpful for emerging editors groups and societies. Increasing awareness of and enforcing the available editorial recommendations is essential for improving the quality of scholarly journals. Journal editors operating in non-Anglophone enrvironment may benefit from a platform enabling discussion of their daily problems, upgrading their skills, and networking with like-minded experts. Ukrainian journal editors can take the lead by establishing their Council with an online communication and publication forum. Such a forum can serve professional interests of regional editors across academic disciplines.</p> 2020-04-14T00:00:00+03:00 Copyright (c) COVID-2019 PANDEMIC: EPIDEMIOLOGICAL ASPECTS 2020-08-04T11:14:19+03:00 Nataliya Vynograd <p><strong>Introduction.</strong> The new COVID-19 pandemic has become a new challenge for all countries in the world, requiring adequate anti-epidemic protection of populations and territories with the purpose to reduce medical, economic, political and other losses due to the rapid spread of the SARS-Cov-2 pathogen. Systems of preparedness and response to biological threats are significantly different at national levels, which has essentially influence at possibility of timely assessment of unusual event and minimization of multiple losses.</p> <p><strong>The aim</strong> of the work was to compare epidemiologically important markers of pandemic course, to evaluate different pandemic’ response tactics in the dynamics of events on different WHO regions.</p> <p><strong>Methods.</strong> Analytical method of complex epidemiological method was used to evaluate of pandemic trends; dynamics and trends were determined according to WHO, euroCDC, CDC (Atlanta, USA), MoH of Ukraine and other online resources.</p> <p><strong>Results.</strong> The rapid spread of the novel coronavirus SARS-Cov-2 has been facilitated by globalization processes, and the delaying of WHO's declared the coronavirus outbreak a Global Public Health Emergency; non-compliance with restrictions on tourist and other migration processes of the population and goods from / to the affected regions. Early contracted the virus as a new pathogenic biological agent with a high epidemic potential has contributed to significant advances in the study of the epidemiological, clinical features of COVID-19, choices of treatment tactics and anti-epidemic measures.</p> <p><strong>Conclusion.</strong> The development of the COVID-19 pandemic was determined by the capacity of national biological threat response systems, the chosen tactics of anti-epidemic protection systems in accordance with the states capacity and the stage of emergency situations in the dynamics of the pandemic in temporal and spatial characteristics.</p> 2020-04-14T00:00:00+03:00 Copyright (c) THE PANDEMIC COVID-2019: IMMUNOLOGICAL FEATURES 2020-08-04T11:27:14+03:00 Valentyna Chopyak <p><strong>Вступ. </strong>COVID-19 – нове захворювання , яке стало викликом для імунної системи людини. Імуні механізми&nbsp; були не готові для&nbsp; захисту на рівні всіх природжених та набутих механізмів. Лише мобілізація імунної системи, її «навчання» можуть дати бій вірусу SARS Cov-2.</p> <p><strong>Метою</strong> <strong>роботи</strong> було аналіз доказових досліджень щодо імунологічних особливостей на&nbsp; рівні природжених та набутих механізмів, різних типів реагування імунної системи людини&nbsp; на COVID-19.&nbsp; &nbsp;</p> <p><strong>Методи.</strong> Використано аналітичний прийом доказовості оцінювання імунологічних методів щодо функціонального стану імунної системи хворих на COVID-19 у порівнянні з&nbsp; практично здоровими людьми на основі доказових наукових пошукових баз PubMed, MedLine, SpringerOpen &nbsp;The Journal of the American Medical Association (JAMA), The Cochrane Librar, &nbsp;Medknow, Google Scholar, BioMed Central,&nbsp;EBSCO – ERIC, а також &nbsp;&nbsp;джерел ВООЗ, euroCDC, CDC (Atlanta, USA), МОЗ України.</p> <p><strong>Результати. </strong>Імунна система відповідає на контакт з SARS-CoV-2 своїм природженим і набутим імунітетом. &nbsp;Відомі порушення природжених механізмів імунної системи: рецепторний апарат(TLR,RIG, NOD, CLR, CDR)&nbsp; антигенпрезентуючих клітин, активності НК-клітин, надмірна продукція хемокіну 10 тощо. Адаптивний імунітет характеризується надмірною активністю Т-хелперів 17, 1 типів з надмірним виділення прозапальних інтерлейкінів IL17,IL6,IL1 тощо та недостатністю функції Т-хелперів 3 типу. Активніть В-лімфоцитів проявляється продукцією більше 30 видів моноклональних актитіл. Особливості імунної відповіді на &nbsp;SARS Cov-2 у людській популяції: 30 % - безсимптомні відповідачі (фізіологічна імунна відповідь), 55 % - легкий перебіг ( скоординована робота імунної системи) , 10 %- середньо-тяжкий перебіг&nbsp; ( дефіцит імунної системи, гіперактивність імунної системи) , 5 % - тяжкий перебіг ( значний дефіцит імунної системи, цитокіновий «шторм», розбалансування імунної відповіді).</p> <p><strong>Висновок.</strong> Необхідне подальше вивчення імунних механізмів для оцінки формування специфічного імунітету, попередження імунозалежних&nbsp; ускладнень , що дасть можливість&nbsp; створити&nbsp; вакцини до SARS-Cov-2, специфічні імуноглобуліни, моноклональні антитіла.</p> 2020-04-14T00:00:00+03:00 Copyright (c) BETWEEN SCYLLA AND CHARYBDIS: COVID-19 AND CANCER (LITERATURE REVIEW) 2020-08-04T11:28:23+03:00 Yaroslav Shparyk <p>The global spread of an infectious disease called COVID-19 which is caused by SARS-CoV-2. continues. The adverse course of COVID-19 is most often observed in patients with comorbidities, in particular malignant tumours. The application of active antineoplastic therapy (chemotherapy, immunotherapy, radiation exposure) can have a negative effect on the course of COVID-19. Therefore, systemic cancer treatment must account for the risk/benefit ratio. For each cancer patient, several factors, including age and comorbidities, and even the need to visit a hospital, may increase this risk. It is recommended to consider several variables, including the degree of the epidemic, capacities of local healthcare structures, the risk of patient's infection, the activity of malignancy, patient comorbidities, age, and treatment peculiarities. There are no simple and universal recommendations for providing cancer care during a crisis, and the inability to estimate the pandemic duration aggravates the issue. This literature review analyzes the experience of oncologists from different countries concerning diagnostic and therapeutic tactics for cancer patients during the pandemic. Practical recommendations on various types of tumours and treatment methods, determining priorities in the operation of oncological facilities, and rational use of financial and professional resources are considered.</p> 2020-04-14T00:00:00+03:00 Copyright (c) COVID-19: NEW DISEASE AND CHAOS WITH PANIC, ASSOCIATED WITH STRESS 2020-08-04T11:29:52+03:00 Sandor Szabo <p>COVID-19 (<strong><u>co</u></strong>rona<strong><u>vi</u></strong>rus <strong><u>d</u></strong>isease – 20<strong><u>19</u></strong>) caused by SARS-CoV-2 (also known as 2019-nCoV) is a new infectious disease by etiology, but in manifestations it has some similarities with SARS (Sever Acute Respiratory Syndrome) that ravaged several countries of the world around 2003. Coronaviruses are RNA containing microbes that ‘hijack’ mammalian cells to replicate themselves intracellularly, just to be released in large quantities. SARS-CoV-2 first replicates in the upper respiratory tract, as opposed to SARS-CoV viruses in the ‘old’ SARS that attack the lower respiratory tree, especially the lungs and cause severe pneumonia. About 80% of COVID-19 patients are mild, some of them are even asymptomatic and only about 10-20% require hospitalization because of pulmonary edema and rapidly developing bronchopneumonia that often leads to multiorgan failure, especially in older patients with chronic comorbidities or immunocompromised system (e.g., obesity, diabetes mellitus, cardiovascular diseases).&nbsp; The overall worldwide mortality is about 1-2%, but some of the genetic variants of the virus caused 4-6% mortality, especially in densely populated areas, like Northern Italy, New York city, Spain. In the most severe cases a ‘cytokine storm’ (a massive release of cytokines) have been described that aggravate the initial damage in the lungs and heart. Epidemiologically, the true incidence and prevalence of COVID-19, most likely, will never be known because of uneven testing in most of the countries for the viral RNA and/or for the developed IgM and IgG antibodies against the virus. From public health perspectives, the hardest hit areas of the world are those that were not prepared, had a poorly organized or underfunded public health service, and/or did not follow the preventive measures such as social distancing, isolation and frequent hand washing. The poor organization of public health services, especially if associated with initial denial of the rapid spread of the disease lead to chaos, panic and, predictably, sever distress in many people</p> 2020-04-15T00:00:00+03:00 Copyright (c) 2019-NCOV PANDEMIC: IMPACT ON REPRODUCTIVE HEALTH 2020-08-04T11:32:36+03:00 Yulian Mytsyk <p>The World Health Organization has declared a pandemic of coronavirus disease (COVID-19, SARS-CoV-2). There is limited evidence regarding the negative impact of COVID-19 infection on the reproductive health of women and men. &nbsp;Previous coronavirus outbreaks in recent years are known to include severe acute respiratory syndrome (SARS) in 2002-03 and Middle East respiratory syndrome (MERS), first reported in 2012. These syndromes may have different effects on the sexual and reproductive health of both men and women at the individual, systemic and social levels. There are no reports that pregnant women are more susceptible to COVID-19 than the general population. However, it is known that pregnancy is still a risk factor for severe illness and death in influenza outbreaks. When studying the patterns of ACE2 expression in the testes of an adult at the level of a single cell transcript, and based on Gene Set Enrichment Analysis (GSEA), it was shown that the categories of genetic ontology (Gene Ontology categories) associated with the reproduction and transmission of virus in ACE2 -positive spermatogonia are present to a large extent, while the levels of compounds related to the generation of gametes in men are suppressed. Such evidence suggests that testicular tissue may be a target for COVID-19. This concise review provides an overview of the scientific literature that discusses the occurrence of complications associated with SARS-CoV-2 transference in the context of the fertile potential of both sexes, the impact on pregnancy, and long-term outcomes of infectioning. In addition, the controversial aspects of this issue are highlighted in the light of molecular biology</p> 2020-04-15T00:00:00+03:00 Copyright (c) MOLECULAR SUBTYPES OF MUSCULAR INVASIVE BLADDER CANCER 2020-08-04T11:14:35+03:00 Oksana Sulaieva Oleksii Seleznov Dmytro Shapochka Roman Ponomarchuk Oleksandr Stakhovsky Natalia Stefiniv <p>This review analyzes the current view on molecular subtypes of muscle-invasive bladder cancer (MI-BC), its key biomarkers, and recommended treatment approaches. Several variants of molecular classifications of BC are known, including the classification of Baylor College of Medicine (BCM), the University of North Carolina (UNC), the MD Anderson Cancer Center (MDA), the Atlas Cancer Genome Project (TCGA), and Lund (Sweden). Nowadays, a consensus international classification of MI-BC has been developed, which not only deepened understanding of the biology of the BC but also showed the relationship of certain genomic disorders with specific morphological subtypes, as well as the clinical pass of the BC. The developed variants of molecular classifications of MI-BC allow not only to predict the course of the tumour process but also stratify patients according to the likely response to chemotherapy and immunotherapy. However, the implementation of molecular classification of MI-BC into clinical practice has several limitations and requires validation studies</p> 2020-04-14T00:00:00+03:00 Copyright (c) CELL-BASED DIAGNOSTIC OF BRONCHIAL CARCINOMA: CASE STUDY OF A DIAGNOSTIC VALUE OF TESTS OF CIRCULATING TUMOR CELLS AND ORGANOID CULTURE 2020-08-04T11:14:38+03:00 Nazariy Souchelnytskyi Andriy Kost Serhiy Souchelnytskyi <p>Diagnostic based on analysis of living tumor cells is frequently used in oncology. Circulating tumor cells in the blood and cells obtained from a tumor biopsy are used to access their carcinogenic properties and subsequently to predict possible development of the disease. Here we report use of these two tests to assess aggressiveness and metastatic potential of a bronchial adenocarcinoma. The circulating tumor cells test was negative, no circulating cells was observed. It indicates that there was no metastatic spread. However, test with the surgery biopsy showed presence of aggressive cellular clones. The tumor cells from the biopsy proliferated and spread from the cultured tissue. Moreover, the tumor cells formed colonies of cells which lost contact inhibition. This is an indication of aggressive carcinogenic features of the cells in tumor organoids. Combination of both tests showed that the local tumor had an aggressive phenotype, but no detectable spreading of cells. Therefore, these tests support a management plan with removal the primary tumor and regular monitoring, without need of an extensive chemotherapy.</p> 2020-04-14T00:00:00+03:00 Copyright (c) COMPARATIVE ANALYSIS OF ANTIMICROBIAL AND FUNGICIDAL ACTIVITY OF COMMONLY AVAILABLE HAND SANITIZERS AND ANTIBACTERIAL WET WIPES ON UKRAINIAN MARKET 2020-08-04T11:14:41+03:00 Nadiia Lekhniuk Solomiia Mykytiuk Roksolana Konechna Roksolana Shykula Olena Korniychuk Yulian Konechnyi <p><strong>Introduction.</strong> Hand sanitizers and antibacterial wet wipes usage are one of the essential (after hand washing) preventive methods for fecal-oral, and airborne transmitted infections, COVID-19 in particular. WHO and MoH of Ukraine recommend regular use of hand sanitizers during the world pandemic. Nevertheless, in Ukraine, unlike European Union countries, takes place the lack of legislative framework, which should ensure effective control of commonly available antiseptic products antibacterial or antiviral activity.&nbsp; On the contrary, during SARS-CoV-2 pandemic, MOH of Ukraine has simplified the registration procedures for the new disinfectants, which raises the chance of ineffective antiseptics appearance due to its growing demand.</p> <p><strong>Objectives.&nbsp;</strong>The research aimed to test the antibacterial and antifungal activity of commonly available Ukrainian hand sanitizers and antibacterial wipes.</p> <p><strong>Methods.&nbsp;</strong>Thirty-six samples were tested, among them 19 (52.8%) antibacterial wet wipes and 17 (47.2%) hand sanitizers, which include 5 (13.9%) gel antiseptics and 12 (33.3%) spray antiseptics.</p> <p>Sample names were next:&nbsp;</p> <ul> <li class="show">Wet wipes: «Naturelle», «Smile with alcohol», «Smile baby», «Smile with D-panthenol», «Smile with plantago juice», «Viva Fruts», «Zeffir», «Hliantz», «Chicolino», «Green Way», «Lili», «Novax», «Ozon», «Ruta», «Superfresh», «Supero», «Dobryi Dotyk», «Snizhna Panda», «Siela»;&nbsp;&nbsp;</li> <li class="show">Gel antiseptics: «Vital Charm», «Wash Your Body», «Doctor Biokon», «Manorm», «Aromat»</li> <li class="show">Spray antiseptics: «Altamed», «Colour intense», «Pro Ecolek», «Green Way», «Lucky Day», «Manorm», «Wash Your Body», «Antyseptychna ridyna», «Argenvit», «Aniospray», «Sribna Voda», «Tsilytel’»</li> </ul> <p>For antibacterial and antifungal activity observation agar well diffusion method was used, with testing on the following reference cultures and clinical isolates of microorganisms (from patients with nosocomial infections):&nbsp;<em>Escherichia</em> <em>coli</em> АТСС 25922; <em>Staphylococcus</em> <em>aureus</em> АТСС 26923 (F-49); <em>Candida</em> <em>albicans</em> АТСС 885/653;&nbsp; <em>Pseudomonas</em> <em>aeruginosa</em> ATCC 27853 (F-51, <em>Escherichia</em> <em>coli</em> №5; <em>Candida</em> <em>albicans</em> №60; <em>Candida</em> <em>non</em><em>-albicans</em> №67; <em>Raoultella</em> <em>terrigena</em> №1; <em>Staphylococcus</em> <em>lentus</em> № 19; <em>Brevundimonas</em> <em>vesicularis</em> №111; <em>Citrobacter</em> <em>sedlakii</em> №37; <em>Pseudomonas</em> <em>aeruginosa</em> №13; <em>Enterococcus</em> <em>spp</em><em>. </em>№161<em>;</em> <em>Aerococcus</em> <em>viridans</em> №26.</p> <p><strong>Results</strong>.&nbsp;<a href="">Among</a>&nbsp;the&nbsp;<a href="">specimens</a>&nbsp;studied, 36.1% (n=13) did not have required antimicrobial activity. From gel antiseptics samples 60.0% (n=3) were partially or completely inactive, from spray antiseptics – 50.0% (n=6). So, every second hand sanitizer can not be used for infectious diseases spreading prevention. Among the wet wipes samples 21.0% (n=4) have shown insufficient antimicrobial activity.</p> <p><strong>Conclusions.&nbsp;</strong>Proper handwashing with correct technique usage remains one of the most crucial methods for fecal-oral, and airborne transmitted diseases prevention. Including the research results, it is better to use hand sanitizers, and antibacterial wet wipes produced by well-known brands and bought in pharmacies, with preference to alcohol-based gel antiseptics, as the efficacy of active ones was the highest.</p> 2020-04-14T00:00:00+03:00 Copyright (c) RENAL ONCOCYTOMA MANAGEMENT IN ADVANCE RENAL FAILURE. A CASE BASED REVIEW 2020-08-04T11:14:44+03:00 Akbar Mahmood Ali Lawati <p>The presentation of a renal mass presumes a malignancy unless proven otherwise by histologic evaluation. We present a case of 40-year-old man with advance uremia necessitating renal replacement. Radiologic images showed a right renal mass and the patient underwent a nephrectomy. The pathologic diagnosis was a benign renal neoplasm, oncocytoma. This neoplasm is not a cause of renal failure but may be associated with other malignant lesions. Focal segmental glomerulosclerosis was the reason for renal failure. Lesion was discovered incidentally during the workup of chronic kidney disease. Histopathology delineated two separate pathologies designing the management plan. After few months of hemodialysis patient could receive renal transplant, a therapy of choice as oncocytoma is a benign condition which doesn’t preclude transplantation.</p> 2020-04-14T00:00:00+03:00 Copyright (c) ANATOMY OF AORTIC DISSECTION IN THE PATIENT WITH MARFAN SYNDROME WHO UNDERWENT SURGERY: A CASE REPORT 2020-08-04T11:14:46+03:00 Uliana Pidvalna Dmytro Beshley Lesya Mateshuk-Vatseba Vitaliy Averchuk Liubomyr Kulyk <p><strong>Introduction. </strong>Aortic dissection is the most common acute aortic pathology. Acute ascending aortic dissection is a life-threatening condition and a surgical emergency which requires prompt visualization of the aortic anatomy. Various types of classification and assessment of the aorta are described.</p> <p><strong>Presentation of the case.</strong> Concurrent aortic dissection and Marfan syndrome (MS) followed by the aneurysm of aorta which required supracoronary aortic replacement (2012), Bentall procedure (2014) and urgent open thoracic descending aorta replacement (2017) are described in the case-report.</p> <p><strong>Discussion. </strong>Patients with the aortic dissection may have certain underlying conditions, such as MS, which can predispose to dissection. The aortic pathology is registered in almost 65-100% of the patients with MS. The prevalence of type A aortic dissection among the patients with MS at the age of 60 is approximately 50%. The most common pattern of repair is the proximal ascending aortic repair followed by the descending thoracic aneurysm surgery. The open surgery technique as well as the aortic dissection or aneurysm repairs may be safely used in the patients with MS.</p> <p><strong>Conclusion.</strong> Anatomical features of the aorta in the patients with MS are vitally important when carrying out the analysis of the computed tomography images; in particular, the schedule of the computed tomography follow-up for the patients with MS should be customized to each case.</p> 2020-04-14T00:00:00+03:00 Copyright (c) YURIY LYPA IS A DOCTOR AND A CITIZEN (To the 120th Birthday) 2020-08-04T11:14:50+03:00 Oleksandr Kitsera <p><strong>Yuriy Lypa,</strong>&nbsp;born May 5, 1900 in Odessa (alternatively – in Stari Sanzhary in Poltava region) as a young man involved in the liberation struggle of the Ukrainian people in the Haidamatsky Division, as well as the launch of the Marine Corps of the UPR Armed Forces. He studied medicine at the University of Poznan (1922 - 1929), and at the same time conducted social and political work among students – Ukrainians in the secret society organized by him – the Black Sea corporation. He acts as a spokesman for the European integration of Ukraine and its religious unity. Author of poetic collections «Excellency», «Harshness», and others, the novel «Cossacks in Muscovy» (191934), collections of storys «Notebook».</p> <p>The great belief in the supreme idea of ​​Ukraine, its traditions, spiritual strength, orientation towards Europe, work on its own style, struggle again &nbsp;provincialism, Little Russian witchcraft and tearful lyricism are the basic slogans and principles that young writers created. Interspersed with these ideas, overflowing with the spirit of struggle for the Ukrainian idea, in 1931 the second collection of poems of Yuri Lypa with such a characteristic name – «Harshness» appeared. «The Appointment of Ukraine» (1938), «The Black Sea Doctrine» (1940), and «The Distribution of Russia» (1941), which outline the current principles and directions of Ukrainian geopolitics. He was co-creator of the Ukrainian Black Sea Emigration Institute in Warsaw, a scientific institution to study the political and economic problems facing Ukraine after independence.</p> <p>While in emigration he thoroughly studied phytotherapy, published a number of articles and textbooks on phytotherapy, a number of his works are cited in Polish works to this day.</p> <p>In 1943 he moved to Yavoriv near Lviv, where he worked as a doctor and trained sanitary personnel for the Ukrainian Insurgent Army, assisting the soldiers of that army as a battalion doctor (colonel). Arguably arrested and savagely murdered by Soviet special services on August 20, 1944.</p> <p>This publication covers the history of honoring the memory of Yuri Lypa by Lviv physicians, his activities as a phytotherapist, and his collaboration with Metropolitan Andrey Sheptytsky.</p> 2020-04-14T00:00:00+03:00 Copyright (c) COMPARABLE CHARACTERISTICS OF BIOLOGICALLY DRIVEN EATING BEHAVIOR IN DIFFERENT ETHNIC GROUPS OF MEDICAL STUDENTS 2020-08-04T11:14:52+03:00 Barbara Belka Iryna Muzyka Taras Gutor Oksana Zayachkivska <p><strong>Introduction:</strong> Eating behavior is one of the key factors which may lead to eating disorders, including obesity and metabolic diseases. It is different among ethnically and socio-culturally diverse groups and strongly related to the influence of various factors, including the contribution of environment and lifestyle, especially for young people.&nbsp;</p> <p><strong>Aim: </strong>To examine the lifestyle-related eating behavior pattern of foreign medical students from Danylo Halytsky Lviv National Medical University (LNMU, Ukraine) in the different ethnic groups.</p> <p><strong>Methods: </strong>The study group includes 209 respondents who are foreign students (aged 17 to 28) who studied in LNMU while residing in dormitories or rented apartments. Participants were surveyed using the English version of the Dutch Eating Behavior Questionnaire DEBQ (Van Strien et al., 2002) and additional original questions about nutritional interventions for healthy food habits. BMI was calculated based on self-reported height and weight. Statistical analysis with JAMOVI provided Cronbach’s α coefficient analysis.</p> <p><strong>Results: </strong>Ethnic groups involved in the study were: African – 16.1%, Asian – 39.2%, European – 41.4%, Hispanic – 1.4%, Mixed – 1.9%.</p> <p>According to the 1st section, eating pattern changes, if the food smells, looks and tastes good, and 54% of total participants (TPs) tend to eat more than they planned; 68.9% will have the desire to eat even if they are not hungry, and 53.2% will eat immediately after they purchase these foods. Obtained data in the 2nd section (emotional eating) has shown that the influence of negative emotions and states like feeling depressed was present in 42.1% of TPs, lonely – 51.4%, anxious, sad, overwhelmed – 30.7% when participants tend to overeat. The 3d section concerns the tendency for external eating. 64.6% of participants tend to overeat during meetings with friends, and 67.5% choose to give food as a gift when they go on a visit. 46.4% of participants tend to overeat on holidays, vacations, hiking trips. The 4th section is about nutritional interventions – 69.3% of TPs eat less than usual, try to avoid snacks; 56.0% of participants choose their food intentionally, are mindful of consumed calories if they want to lose weight; 52.6% choose to eat less during the day if they consumed too many calories the day before.</p> <p><strong>Conclusion: </strong>Taken together with the results from different ethnic groups, the association between the emotional condition and eating behavior differed depending on the ethnicity. Most of the participants know about principles of healthy eating, but they also realize that their eating behavior changes to adapt to current lifestyle factors, like gender, chronic stress, demanding academic learning, sedentary lifestyle, and macro-social factors.</p> 2020-04-15T00:00:00+03:00 Copyright (c) “SYSTEMIC LYPUS ERYTHEMATOSUS, DIAGNOSTIC, TREATMENT, PREVENTION” / V. V. Chopyak, Ja. F. Tolstyak, K. E. Ishejkin, O. V. Synenkyy, I. G. Hajduchok ; – Lviv: ZUKC, 2019. – 270 c. 2020-08-04T11:36:06+03:00 Volodymyr Kovalenko <p>Бурхливий розвиток медицини та науки&nbsp; створив підґрунтя для дослідження та покращення&nbsp; лікування – системного червоного вовчака: захворювання «хамелеона», яке часто маскується під іншими захворюваннями та в переважній більшості свого перебігу&nbsp; уражує багато органів та систем. &nbsp;На сьогоднішній день недостатньо знати клініку та лікування &nbsp;хвороби, а необхідно розуміти&nbsp; глибинні механізми патогенезу&nbsp; хвороби з метою доцільності призначення «таргетної» терапії. Теоретичний багаж знань у напрямку дослідження&nbsp; системного червоного вовчака, їх практичне використання широко обговорює світова наукова спільнота: на міжнародних форумах, конгресах товариства ревматологів, у щоквартальному&nbsp; фаховому журналі “Український ревматологічний журнал”.&nbsp; На жаль, у межах України проведення великомасштабних&nbsp; когортних досліджень &nbsp;ревматологічного напрямку &nbsp;обмежене. Відкрита публікація монографії “CИСТЕМНИЙ ЧЕРВОНИЙ ВОВЧАК діагностика, лікування, профілактика”&nbsp; є одною з перших монографій в Україні, в якій сконцентровано ключові положення системного червоного вовчака. Детально висвітлено будову та функції імунної системи при хворобі, охарактеризовано&nbsp; аутоантитіла, що специфічно &nbsp;змінюються при системному червоному вовчаку.&nbsp; Описано основні етапи &nbsp;патогенезу, а також сучасний стан досліджень &nbsp;системного червоного вовчака в Україні та світі.</p> 2020-04-15T00:00:00+03:00 Copyright (c) PHYSIOLOGY, INCLUDING THE PHYSIOLOGY OF THE MASTICATORY APPARATUS. Part 2: The textbook for practical classes and independent work of students (masters) of the Faculty of Dentistry /edited by OS Zayachkivska. 2020-08-04T11:37:07+03:00 Tetiana Zaporozhets <p>Нещодавно світ побачив навчальний посібник для практичних занять та самостійної роботи студентів (магістрів) стоматологічного факультету «Фізіологія, в тому числі й фізіологія жувального апарату» за редакцією професора Оксана Заячківської, підготовлений співробітниками кафедри нормальної фізіології Львівського національного медичного університету імені Данила Галицького, виданий в університетському видавництві. Матеріал книги &nbsp;організований у відповідності до робочої кафедральної програми, стандартів та критеріїв компетентності з дисципліни «Фізіологія, в тому числі й фізіологія жувального апарату» для студентів стоматологічного факультету, що відповідає вимогам та критеріям компетентності з точки зору доказової медицини та стоматології.</p> <p>Актуальність та необхідність підготовки видання даного посібника ґрунтується на викладанні дисципліни фізіологія студентам-стоматологам, що базується на принципах формування у них клінічного мислення у спосіб вирішення клінічних задач та ситуаційних завдань для підготовки спеціалістів другого (магістерського) рівня знань у системі охорони здоров’я, у відповідності до освітньо-кваліфікаційних характеристик та освітньо-професійних програм підготовки спеціалістів стоматологічного профілю.</p> 2020-04-15T00:00:00+03:00 Copyright (c) Borys Bilynsky. ATYPICAL ONCOLOGY. Textbook for physicians / Borys Bilynsky ; by edition Yaroslav Shparyk. – Lviv, Afisha, 2020. – 386 p. 2020-08-04T11:38:02+03:00 Ivan Gout <p>I felt a personal connection to this book before even reading it, as Danylo Halytsky Lviv National Medical University is my Alma Mater and my career path in cancer research was inspired by Prof. B. Bilynsky, who was the Head of Oncology Department during my study. Surfing through a pdf file of the “Atypical Oncology” textbook by Prof. B. Bilynsky, I prepared myself for guidance on the current state of diagnostic and treatment of atypical tumours, and an optimistic message about how the cancer field in general is moving forward.</p> <p>The book has a simple, but catchy title, and the introduction provides a guiding light throughout the following chapters of the textbook, focusing in particular on advances in cancer diagnostics and the importance of personalised treatment of atypical oncology.&nbsp;</p> <p>A diverse range of atypical cancers is covered in chapters and the main focus is given to unique features of their morphological appearance, unpredictability of disease progression and treatment outcomes. The information provided is very detailed and the use of selected case studies will be of particular interest not only for medics studying oncology and junior oncologist, but also for well-established clinicians/researchers in field of clinical and experimental oncology.</p> <p>Prof. B. Bilynsky ends his book with a chapter that summarizes why he believes that a combination of diverse diagnostic approaches (histo- and immunohistochemistry, molecular and genetic tests, and sophisticated imaging modalities) is essential for successful treatment of common and rare atypical tumours, and winning eventually the “war” on cancer with the development of novel anti-cancer therapies.</p> <p>The book highlights two different strategies which are currently used for the management of atypical tumors: standard treatment regimens and a personalized approach.</p> <p>I find the book informative, compelling and written in a way that will attract the attention not only oncologists and medical staff of diagnostic services, but also researchers working in the field of cancer biology.&nbsp;</p> <p>Prof. Bilynsky’s journey in the field of oncology is inspirational and spans years of dedication to his clinical, research and academic endeavour. This book summarises an extensive amount of personal expertise in clinical oncology which is closely interlinked with collaborative studies and the up-to-date knowledge on atypical cancers, and I strongly recommend it for cancer specialists.</p> 2020-06-02T00:00:00+03:00 Copyright (c) SCIENCE AND GENDER EQUALITY 2020-08-04T11:38:59+03:00 Yaryna Pohoretska Khrystyna Dzhyoieva <p><em>’’Єдиний спосіб дістатися вершини драбини - долати сходинку за сходинкою, по одній за раз. І в процесі цього підйому, Ви не очікувано побачите у себе всі необхідні якості, навички та вміння, необхідні для досягнення успіху, котрого Ви, начебто ніколи не мали…’’&nbsp; </em><strong><em>Маргарет Тетчер</em></strong></p> <p>Щорічно, з 2016 року, за рішенням ООН відзначається Міжнародний день жінок і дівчат у науці (International Day of Women and Girls in Science). За сприянням Наукового Товариства ім. Шевченка (НТШ) у Львові 11 лютого 2020 року в приміщенні Львівського Будинку вчених відбулося відзначення жінок, які досягли чимало успіхів в розвитку науки.<br>За даними Інституту статистики ЮНЕСКО, лише 28% наукових працівників у світі – жінки. Це свято присвячене гендерній рівності жінок в освіті, в сфері праці, в політиці та розширенні їх прав і можливостей.<br><br></p> 2020-04-15T00:00:00+03:00 Copyright (c) PRIMUM NON NOCERE 2020-08-04T11:45:06+03:00 Olga Holubovska <p>The co-author of the Ministry of Health of Ukraine Protocol "Providing Health Care for Coronavirus Disease 2019 (COVID-19) Treatment” aimed to combat COVID-19 presented the preconditions of its creation. Ukraine was faced with COVID-19 at the start of its reforms to the secondary stage of medical care. In addition, there were no regulative documents in the country that would allow doctors to prescribe treatment to patients with COVID-19 using drugs that proved their effectiveness. Since there still no official recommendations in the world concerning the use of drugs to treat COVID-19 that would be grounded on the evidence-based medicine (such evidence will be obtained at a later stage as data is analyzed), the entire world is now using these treatments as part of clinical trials only. According to WHO, such experimental treatment is now being carried out using over 230 different means, including immunobiological drugs, while in the USA, “Extended access to compassionate use” program was approved by the US Food and Drug Administration (FDA).</p> <p>The Law of Ukraine “On Amending Some Legislative Acts of Ukraine Aimed at Preventing the Occurrence and Spread of Coronavirus Disease (COVID-19)” states that “ coronavirus disease (COVID-19) treatment and/or prevention methods may be used to treat patients with coronavirus disease (COVID-19) confirmed by the laboratory testing if such coronavirus disease (COVID-19) prevention practices and/or treatment are allowed by the official bodies of the USA, European Union Member States, United Kingdom, Swiss Confederation, Japan, Australia, Canada, People’s Republic of China, the State of Israel to treat and/or prevent COVID-19 in the respective country or the territory of the European Union based on the decision of the central executive authority responsible for shaping and implementing the state policy in the field of health care subject to the patient’s consent to relevant medical intervention.</p> 2020-06-02T00:00:00+03:00 Copyright (c) CARDIOPULMONARY RESUSCITATION AND INTENSIVE CARE IN PATIENTS WITH CORONAVIRUS DISEASE (CLINICAL CASES) 2020-08-04T11:46:19+03:00 Natalia Matolinets Oleh Samchuk <p>This is an analysis of cardiopulmonary resuscitation and intensive care of patients suffering from the pandemic spread of the coronavirus COVID-19. High contagiousness of COVID-19, its asymptomatic or, on the contrary, severe course, difficulties with early laboratory confirmation of the diagnosis all leads to increased risks of staff infection, especially in the departments of anaesthesiology and intensive care (AIC). Therefore, a clear understanding of the algorithms of resuscitation procedures and principles of medical staff protection is critical. To fight the coronavirus disease (COVID-19), the practical experience based on the application of the protocol adopted by the Ministry of Health of Ukraine No 722 "Organization of Medical Care for Patients with Coronavirus Disease (COVID-19)" dated March 28, 2020, is described.</p> 2020-06-02T00:00:00+03:00 Copyright (c) LIFE DEVOTED TO SCIENCE (on the occasion of Prof. Rostyslav Stoyka’s anniversary) 2020-08-04T11:46:55+03:00 Lesya Kobylinska <p>Professor Rostyslav Stoika (May 23, 1950) – a well-known scientist in the field of biochemistry, cell and molecular biology. Corresponding Member of the National Academy of Sciences of Ukraine, "Biochemistry" (2006), Laureate of the Palladin Prize in Biochemistry of the USSR Academy of Sciences (1987), winner of the Kavetsky Prize in Experimental Oncology of the National Academy of Sciences of Ukraine (2007), Soros Professor of Biochemistry (1997), a foreign member of the Polish Academy of Sciences and Arts in the Section of Natural Sciences (2002), a full member of the Shevchenko Scientific Society (2004). Stoika R.S. initiated in Ukraine a study of the role and mechanisms of programmed cell death – apoptosis. Today, the department headed by Stoyka R.S. focuses on <em>in vitro</em> and <em>in vivo</em> bio-testing of new nanoscale drug delivery systems for drugs and genes to cells for medicine and biotechnology. Rostyslav Stoika – author and co-author of more than 720 scientific publications, including 360 papers in scientific journals with a total impact factor of more than 260. Co-author of 5 monographs and sections in 16 monographs, including in 9 monographs of international publishers, 3 methodical manuals, 17 patents of Ukraine for inventions and utility models, and also 2 applications for patents of the USA and the Europe</p> 2020-06-02T00:00:00+03:00 Copyright (c)