ACUTE KIDNEY INJURY INDUCED WITH INTRAVENOUS CONTRAST AGENTS FOR MEDICAL RADIOLOGICAL INTERVENTIONS: INCIDENCE AND DETERMINATION OF THE INFLUENCING FACTORS

Abstract

Medical radiological diagnostic or therapeutic interventions are widely used as routine medical procedures in patients of all ages. At the same time, radiographic contrast agent exposure has been increasingly blamed for acute kidney injury (AKI) which reduces patients’ quality of life. This study aimed to explore the diff erences in incidence and infl uencing factors for AKI and its subtypes among patients after radiological diagnostic or therapeutic interventions with intravenous contrast agents, including computed tomography (CT), angiography, and magnetic resonance imaging (MRI). This observational study included 8060 patients (from the large nephrological clinic in Berlin, Germany) and AKI was diagnosed according to AKIN criteria ranging. The pooled prevalence of AKI was 9 %. Patients with AKI aged 60–79 years (51%) and 80–100 years (37%), respectively, were predominant. AKI was signifi cantly associated with using iodinated radiographic contrast agents (94 %) after CT and angiography and 92 % of patients had AKIN 1. The prevalence of AKIN 2 and AKIN 3 was higher among patients after MRI with non-iodinated radiographic contrast agents. To sum up obtained results, the incidence of AKI among patients after intravenous contrast agents for medical radiological interventions is low. Diff erences in the prevalence of AKI were found to be related to age and the type of contrast agents used.