Keywords: Sense of smell, taste, chemosensory dysfunction, COVID-19, coronavirus infection, quality of life


Introduction. Olfactory disorders are observed in infectious and non-infectious diseases, but caused a new wave of attention as one of the fi rst and often the only symptoms of COVID-19 at the beginning of the pandemic.

Aim. To evaluate the prevalence, degree, duration of olfactory and taste disorders in patients with COVID-19, their relationship with the severity of the disease and the impact on the quality of life.

Materials and methods. 699 patients after COVID-19 were interviewed using the electronic questionnaire, which was developed based on the available data and our observations about the most common symptoms in COVID-19 patients. The questionnaire consisted of 35 main questions on the topic of the study organized in 3 sections. Response forms were closed, semi-closed or open. Two questions on screening for mood disorders were taken from the Patient Health Questionnaire (PHQ). Patients were asked to rate their sense of smell and taste on a 10-point visual analog scale (VAS).

Results. In most cases, olfactory and taste impairment occurred immediately after the appearance of other symptoms reaching a peak on 3-5th days of illness and did not improve after clinical recovery. Patients experienced varying degrees of hypo-, par- and cacosmia, subsequently even changing their food and behavioral habits (such as reducing or quitting smoking).

Conclusions. The recovery of smell and taste had a clear direct correlation. More than half of the patients needed an in-depth assessment of their mental health most likely due to the combination of factors, including the impairment of smell and taste.


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Croy I, Nordin S, Hummel T. 2014. Olfactory disorders and quality of life-an updated review. Chem Senses. 39(3):185-194.

Philpott CM, Boak D. 2014. The impact of olfactory disorders in the United Kingdom. Chem Senses. 39(8):711-718.

Rawal S, Hoffman HJ, Chapo AK, Duffy VB. 2014. Sensitivity and specificity of self-reported olfactory function in a home-based study of independent-living, healthy older women.

Hoffman HJ, Rawal S, Li CM, Duffy VB. 2016. New chemosensory component in the U.S. National Health and Nutrition Examination Survey (NHANES): first-year results for measured olfactory dysfunction. Rev Endocr Metab Disord. 17(2):221-240.

Belka B, Muzyka I, Gutor T, Zayachkivska O. Comparable characteristics of biologically driven eating behavior in different ethnic groups of medical students. Proc Shevchenko Sci Soc Med Sci [Internet]. 2020 Apr.15 [cited 2021Dec.1];59(1). Available from:

Fokkens WJ, Lund VJ, Hopkins C, Hellings PW, Kern R, Reitsma S, Toppila-Salmi S, Bernal-Sprekelsen M, Mullol J. Executive summary of EPOS 2020 including integrated care pathways. Rhinology. 2020 Apr 1;58(2):82-111. doi: 10.4193/Rhin20.601. PMID: 32226949.

Suzuki M, Saito K, Min WP, et al. Identification of viruses in patients with postviral olfactory dysfunction. Laryngoscope 2007;117:272-277.

Hwang CS. Olfactory neuropathy in severe acute respiratory syndrome: report of a case. Acta Neurol Taiwan 2006;15:26-28.

De Haro-Licer J, Roura-Moreno J, Vizitiu A, Gonzàlez-Fernàndez A, Gonzàlez-Ares JA. Long term serious olfactory loss in cold and/or flu. Acta Otorrinolaringol Esp 2013;64:331-338.

Marin C, Vilas D, Langdon C, Alobid I, López-Chacón M, Haehner A, Hummel T, Mullol J. Olfactory Dysfunction in Neurodegenerative Diseases. Curr Allergy Asthma Rep. 2018 Jun 15;18(8):42. doi: 10.1007/s11882-018-0796-4. PMID: 29904888.

van Riel D, Verdijk R, Kuiken T (2015) The olfactory nerve: a shortcut for infuenza and other viral diseases into the central nervous system. J Pathol 235(2):277-287.

Vaira LA, Salzano G, Deiana G, De Riu G. Anosmia and ageusia: common findings in COVID-19 patients. Laryngoscope 2020. 1002/lary.28692

Kítsera O.O. Diagnostika í lecheniye narusheniy obonyaniya (metodicheskiye rekomendatsii dlya prakticheskikh vrachey-otolaringologov). Lvov, 1976. 14 s, prilosheniya. [In Russian].

Yamagishi M, Fujiwara M, Nakamura H. Olfactory mucosal findings and clinical course in patients with olfactory disorders following upper respiratory viral infection. Rhinology 1994;32:118-133.

Rafal Butowt and Christopher S. von Bartheld. Anosmia in COVID-19: Underlying Mechanisms and Assessment of an Olfactory Route to Brain Infection. The Neuroscientist 1-22.2020.

Stefano Pallanti. Importance of SARs-Cov-2 anosmia: From phenomenology to neurobiology. Comprehensive Psychiatry 100 (2020) 152184.

Luigi A. Vaira, Giovanni Salzano, Giovanna Deiana, Giacomo De Riu. Anosmia and Ageusia: Common Findings in COVID-19 Patients Laryngoscope, 00:1, 2020.

Mao L, Jin H, Wang M, Yu H, Chen Sm He Q, and others. 2020. Neurologic manifestations of hospitalized patients with coronavirus disease 2019 in Wuhan China. JAMA Neurol 77(6):1-9. doi:10.1001/ jamaneurol.2020.1127.

Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y, and others. 2020a. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan China: a descriptive study. Lancet 395(10223):507-13. doi:10.1016/S0140-6736(20)30211-7.

Streeck H. 2020. Neue Corona-Symptome entdeckt: Virologe Hendrik Streeck zum Virus. Frankfurter Allgemeine Zeitung Mar 16. corona-symptome-entdeckt-virologe-hendrik-streeck-zum-virus-16681450.html?GEPC=s3.

Hopkins C, Surda P, Kumar N. 2020. Presentation of new onset anosmia during the COVID-19 pandemic. Rhinology 58(3):295-8. doi:10.4193/Rhin20.116.

Parma V, Ohla K, Veldhuizen MG, Niv MY, Kelly CE, Bakke AJ, and others. 2020. More than just smell- COVID-19 is associated with severe impairment of smell, taste, and chemesthesis. MedRxiv preprint. do i:10.1101/2020.05.04.20090902.

Muzyka I, Belka B, Ostrovska Y, Zayachkivska O. Self-perception of changes in lifestyle and wellbeing associated with social distancing during COVID-19 pandemic among medical students (the study in Lviv, Ukraine). Proc Shevchenko Sci Soc Med Sci [Internet]. 2021 Jun.10 [cited 2021Dec.1];64(1). Available from:

Filts O, Fitkalo O, Lyzak O, Berezyuk O, Myshakivska O, Samsonova L, Pritz A. Toward a cohesive clinical interpretation of mental disorders in SARS-CoV-2 pandemic: an expert opinion. Proc Shevchenko Sci Soc Med Sci [Internet]. 2021 Jun.10 [cited 2021 Dec.1];64(1). Available from: index.php/journal/article/view/482

Szabo S. COVID-19: new disease and chaos with panic, associated with stress. Proc Shevchenko Sci Soc Med Sci [Internet]. 2020 Apr.15 [cited 2021 Dec.1];59(1). Available from: php/journal/article/view/281

Sanjeevkumar Gaur P, Gupta L. Changing research paradigm in the face of a global pandemic: foreseeable impact and adaptive measures in academic research in the future. Proc Shevchenko Sci Soc Med Sci [Internet]. 2020 Sep.27 [cited 2021 Dec.1];62(2). Available from: journal/article/view/317

Sormani MP, De Rossi N, Schiavetti I, Carmisciano L, Cordioli C, Moiola L, Radaelli M, Immovilli P, Capobianco M, Trojano M, Zaratin P, Tedeschi G, Comi G, Battaglia MA, Patti F, Salvetti M; Musc-19 Study Group. Disease-Modifying Therapies and Coronavirus Disease 2019 Severity in Multiple Sclerosis. Ann Neurol. 2021 Apr;89(4):780-789. doi: 10.1002/ana.26028. Epub 2021 Feb 9. PMID: 33480077; PMCID: PMC8013440.

Gilbody, S., Richards, D., Brealey, S., & Hewitt, C. (2007). Screening for depression in medical settings with the Patient Health Questionnaire (PHQ): A diagnostic meta-analysis. Journal of General Internal Medicine, 22(11), 1596-1602. 10.1007/s11606-007-0333-y.

Tomlinson D, von Baeyer CL, Stinson J, Sung, L. A systematic review of faces scales for the self-report of pain intensity in children // Pediatrics. 2010; 126 (5): 1168-1198. DOI: 10.1542/peds.2010-1609

Report of the WHO-China Joint Mission on Coronavirus Disease 2019 (COVID-19). docs/default-source/coronaviruse/who-china-joint-mission-on-covid-19-final-report.pdf.

von Bartheld CS, Hagen MM, Butowt R. 2020. Prevalence of chemosensory dysfunction in COVID-19 patients: a systematic review and meta-analysis reveals significant ethnic differences. MedRxiv preprint. doi:10.1101/2020.06.15.20132134

Hannum ME, Ramirez VA, Lipson SJ, Herriman RD, Toskala AK, Lin C, and others. 2020. Objective sensory testing methods reveal a higher prevalence of olfactory loss in COVID-19-positive patients compared to subjective methods: a systematic review and meta-analysis. MedRxiv preprint. doi:10.11 01/2020.07.04.20145870.

Tong JY, Wong A, Zhu D, Fastenberg JH, Tham T. The Prevalence of Olfactory and Gustatory Dysfunction in COVID-19 Patients: A Systematic Review and Meta-analysis. Otolaryngol Head Neck Surg. 2020 Jul;163(1):3-11. doi: 10.1177/0194599820926473. Epub 2020 May 5. PMID: 32369429.

Agyeman AA, Lee Chin K, Landersdorfer CB, Liew D, OforiAsenso R. 2020. Smell and taste dysfunction in patients with COVID-19: a systematic review and meta-analysis. Mayo Clin Proc 95(8):1621-31.

Qiu C, Cui C, Hautefort C, Haehner A, Zhao J, Yao Q, and others. 2020. Olfactory and gustatory dysfunction as an early identifier of COVID-19 in adults and children: an international multicenter study. MedRxiv preprint. doi. org/10.1101/2020.05.13.20100198

Akosua Adom Agyeman, Ken L. Chin, MClinPharm, Cornelia B. Landersdorfer, Danny Liew, MBBS (Hons), FRACP, and Richard Ofori-Asenso. Smell and Taste Dysfunction in Patients With COVID-19: A Systematic Review and Meta-analysis. Mayo Clin Proc. n August 2020;95(8):1621-1631.

Matolinets N, Samchuk O. Cardiopulmonary resuscitation and intensive care in patients with coronavirus disease (clinical cases). Proc Shevchenko Sci Soc Med Sci [Internet]. 2020 Jun.2 [cited 2021 Dec.01];59(1). Available from:

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Moskalyk O, Semenyuk O, Kruk M, Barylyak A, Hayevskyy V, Tynitovska O, Chorniy O, von-Nagy I, Pidkovka N. THE STUDY OF CHEMOSENSORY DYSFUNCTION IN PATIENTS AFTER COVID-19. Proc Shevchenko Sci Soc Med Sci [Internet]. 2022Jun.27 [cited 2022Oct.7];66(1). Available from: