RESEARCH OF CANCER CASES AMONG LONG-LIVED WOMEN IN LVIV REGION (UKRAINE) DURING 1991–2019 YEARS
Abstract
Cancer is the second leading cause of death worldwide.
Aim of our study was to describe the spectrum of cancer among longlivers women in Lviv region (Ukraine) from database during 1991-2019.
Material and methods. We studied 444 longlivers women aged 90+ who were diagnosed of cancer, treated and followed-up.
Results. 104 women (23%) were diagnosed cancer to stage I, II -142 (32%), III -71 (10%), IV -57 (13%):other malignant neoplasms of skin (38.29%), breast (9.46%), colon (6.98%) and pancreas (4.95%) cancer. Diagnosis was confirmed cytology -169 (38.1%), histology-139 (31.3%). CT and MRI were used in rare cases in older women – 11(2.5%). Half of the women (227 or 51.13%) lived beyond 1 year after diagnosis. The rest is from 1 to 13 years.
The relationship between life expectancy after diagnosis of cancer and type of treatment is weak (Сramer ratio ; Pearson's criterion ). Detected that the relationship between life expectancy after diagnosis and the age of patients at the time of oncologic diagnosis is weak too (Сramer ratio ; Pearson's criterion ). The relationship between life expectancy after diagnosis and stage of cancer is strong (Сramer ratio ; Pearson's criterion ).
Conclusion.
Aggressive anticancer treatments are less commonly used in cancer patients aged 90+, which may be one of the reasons for poorer survival due to comorbidities and natural causes. Life expectancy has relationship on the stage of the cancer, but does not have relationship on the age of the long-lived women and the type of treatment.
Downloads
References
Arem H, Loftfield E. Cancer Epidemiology: A Survey of Modifiable Risk Factors for Prevention and Survi- vorship. Am J Lifestyle Med. 2018; 12 (3): 200-210. DOI: 10.1177/1559827617700600
https://doi.org/10.1177/1559827617700600
WHO. Cancer key facts. Geneva: WHO; 2018. https://www.who.int/news-room/fact-sheets/detail/ cancer.
Legrand R, Manckoundia P, Nuemi G, Poulain M. Assessment of the Health Status of the Oldest Olds Living on the Greek Island of Ikaria: A Population Based-Study in a Blue Zone. Curr Gerontol Geriatr Res. 2019; 2019: 8194310. DOI: 10.1155/2019/8194310. eCollection 2019.
https://doi.org/10.1155/2019/8194310
Hotta S, Kameyama H, Shimada Y, Yamada S, Tanaka K, Tajima Y et al. A Case of Long-Term Survival in a Patient with Ascending Colon Cancer and Synchronous Multiple Liver Metastases after Multimodality Therapy Including Multiple Hepatectomy. Gan To Kagaku Ryoho. 2018;45(13): 2464-2466.
Presley C J, Dotan E, Soto-Perez-de-Celis E. Jatoi A, Mohile SG, Won E et al. Gaps in nutritional research among older adults with cancer. J Geriatr Oncol. 2016; 7 (4): 281-292.
https://doi.org/10.1016/j.jgo.2016.04.006
Bulletin of National Cancer Registry of Ukraine. Cancer in Ukraine, 2018-2019. V.21. http://www.ncru. inf.ua/publications/BULL_21/index_e.htm
Evaluation of data quality at the National Cancer Registry of Ukraine. Ryzhov A, Bray F, Ferlay J, Fedorenko Z, Goulak L, Gorokh Y et al. Cancer Epidemiol. 2018;53:156-165. DOI: 10.1016/j.canep.2018.02.002.
https://doi.org/10.1016/j.canep.2018.02.002
Situation of older women in Ukraine (2014). Analytical report/ http://www.un.org.ua/en/
Grybach S.M., Polishchuk L.Z, Chekhun V.F Analysis of the survival of patients with breast cancer depending on age, molecular subtype of tumor and metabolic syndrome.Exp Oncol. 2018; 40 (3): 243-248.
https://doi.org/10.31768/2312-8852.2018.40(3):243-248
Morrow M., Petruolo O. Breast Cancer in Elderly Women. Principles and Practice of Geriatric Surgery. 2017. 1-25. DOI: https://doi.org/10.1007/978-3-319-20317-1_63-1
https://doi.org/10.1007/978-3-319-20317-1_63-1
Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2017: A Systematic Analysis for the Global Burden of Disease Study. Global Burden of Disease Cancer Collaboration, Christina Fitzmaurice, Degu Abate, Naghmeh Abbasi et al. JAMA Oncol. 2019; 5(12): 1749-1768. DOI: 10.1001/ jamaoncol.2019.2996
Bakhrushin VE .Methods of data analysis. A textbook for students. Zaporizhzhya: KPU, 2011. 268 p. [in Ukrainian].
The encyclopaedic companion to medical statistics / ed. by Brian S. Everitt and Christopher R. Palmer; with foreword R. Horton. 2nd ed.2011. 516 p. ISBN: 978-0-470-68419-1.
Population of Ukraine. http://lv.ukrstat.gov.ua/ukr/
Cancer Incidence in Five Continents. Ferlay J, Kraywinkel K, Rous B, Znaor A. Chapter 3: Classification and coding. https://ci5.iarc.fr/CI5-XI/PDF/Chapter %203.pdf
Ng O, Watts E, Bull CA, Morris R, Acheson A, Banerjea A. Colorectal cancer outcomes in patients aged over 85 years Ann R Coll Surg Engl. 2016; 98 (3): 216-221. DOI: 10.1308/rcsann.2016.0085
https://doi.org/10.1308/rcsann.2016.0085
Huang Y, Dai H, Song F, Li H, Yan Y, Yang Z et al. Preliminary effectiveness of breast cancer screening among 1.22 million Chinese females and different cancer patterns between urban and rural women. Sci Rep. 2016; 6: 39459. DOI: 10.1038/srep39459
https://doi.org/10.1038/srep39459
Chargari C, Moriceau G, Auberdiac P, Guy J-B, Assouline A, Tinquaut F et al. Feasibility of Radiation Therapy in Patients 90 years of Age and Older: A French Multicentre Analysis. Eur J Cancer. 2014; 50 (8): 1490-1497. DOI: 10.1016/j.ejca.2014.02.012.
https://doi.org/10.1016/j.ejca.2014.02.012
Suhag V, Sunita BS, Vats P, Singh S, Jain M, Vashisht R. Radiotherapy and geriatric cancer patients: A single institute experience. Indian J Med Sci. 2019; 71 (1): 28-34.
https://doi.org/10.25259/IJMS_10_2019
Hurria A, Soto-Perez-de-Celis E, Allred JB, Cohen HJ, Arsenyan A, Ballman K. Functional Decline and Resilience among Older Women Receiving Adjuvant Chemotherapy for Breast Cancer. J Am Geriatr Soc. 2019; 67 (5): 920-927.
https://doi.org/10.1111/jgs.15493
Allemani C, Weir HK, Carreira H, Harewood R, Spika D, Wang X-S et al. Global surveillance of cancer survival 1995-2009: analysis of individual data for 25 676 887 patients from 279 population- based registries in 67 countries (CONCORD-2). Lancet. 2015; 385 (9972): 977-1010. DOI: 10.1016/ S0140-6736(14)62038-9
https://doi.org/10.1016/S0140-6736(14)62038-9
Mandelblatt JS, Cai L, Luta G, Kimmick G, Clapp J, Isaac C et al. Frailty and Long-term Mortality Of Older Breast Cancer Patients: CALGB 369901 (Alliance). Breast Cancer Res Treat. 2017; 164(1): 107-117. DOI: 10.1007/s10549-017-4222-8.
https://doi.org/10.1007/s10549-017-4222-8
DeSantis CE, Miller KD, Dale W, Mohile SG, Cohen HJ, Leach CR et al. Cancer statistics for adults aged 85 years and older, 2019. CA Cancer J Clin. 2019; 69 (6): 452-467.
https://doi.org/10.3322/caac.21577
Pavlidis N, Stanta G, Audisio RA. Cancer prevalence and mortality in centenarians: a systematic review. Crit Rev Oncol Hematol. 2012; 83 (1): 145-152.
https://doi.org/10.1016/j.critrevonc.2011.09.007
Stanta G, Campagner L, Cavallieri F, Giarelli L. Cancer of the oldest old. What we have learned from autopsy studies. Clin Geriatr Med. 1997; 13 (1): 55-68.
https://doi.org/10.1016/S0749-0690(18)30182-4
Amin A.R.M, Karpowicz PA, Carey TE, Arbiser J, Nahta R, Chen ZG et al. Evasion of anti-growth sig- naling: a key step in tumorigenesis and potential target for treatment and prophylaxis by natural com- pounds. Semin Cancer Biol. 2015; 35 Suppl: S55-S77. DOI: 10.1016/j.semcancer.2015.02.005
https://doi.org/10.1016/j.semcancer.2015.02.005
Mohile SG, Dale W, Somerfield MR, Schonberg MA, Boyd CM, Burhenn PS et al. Practical Assessment and Management of Vulnerabilities in Older Patients Receiving Chemotherapy: ASCO Guideline for Geriatric Oncology. J Clin Oncol. 2018; 36 (22): 2326-2347. DOI: 10.1200/JCO.2018.78.8687
https://doi.org/10.1200/JCO.2018.78.8687
Schwartz RM, Ornstein KA, Liu B, Alpert N, Bevilacqua KG, Taioli E. Change in Quality of Life after a Can- cer Diagnosis among a Nationally Representative Cohort of Older Adults in the US. Cancer Invest. 2019; 37(7): 299-310. DOI: 10.1080/07357907.2019.1645160
https://doi.org/10.1080/07357907.2019.1645160
Mohile SG, Hurria A, Cohen HJ, Rowland JH, Leach CR, Arora NK, Canin B et al. Improving the Quality of Survivorship for Older Adults with Cancer. Cancer. 2016; 122 (16): 2459-2568. DOI: 10.1002/ cncr.30053.
Abstract views: 246 PDF Downloads: 158