2019-NCOV PANDEMIC: IMPACT ON REPRODUCTIVE HEALTH

Keywords: COVID-19, SARS-CoV-2, pandemic, reproduction, testosterone, infertility, pregnancy, complications

Abstract

The World Health Organization has declared a pandemic of coronavirus disease (COVID-19, SARS-CoV-2). There is limited evidence regarding the negative impact of COVID-19 infection on the reproductive health of women and men.  Previous coronavirus outbreaks in recent years are known to include severe acute respiratory syndrome (SARS) in 2002-03 and Middle East respiratory syndrome (MERS), first reported in 2012. These syndromes may have different effects on the sexual and reproductive health of both men and women at the individual, systemic and social levels. There are no reports that pregnant women are more susceptible to COVID-19 than the general population. However, it is known that pregnancy is still a risk factor for severe illness and death in influenza outbreaks. When studying the patterns of ACE2 expression in the testes of an adult at the level of a single cell transcript, and based on Gene Set Enrichment Analysis (GSEA), it was shown that the categories of genetic ontology (Gene Ontology categories) associated with the reproduction and transmission of virus in ACE2 -positive spermatogonia are present to a large extent, while the levels of compounds related to the generation of gametes in men are suppressed. Such evidence suggests that testicular tissue may be a target for COVID-19. This concise review provides an overview of the scientific literature that discusses the occurrence of complications associated with SARS-CoV-2 transference in the context of the fertile potential of both sexes, the impact on pregnancy, and long-term outcomes of infectioning. In addition, the controversial aspects of this issue are highlighted in the light of molecular biology

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Published
2020-04-15
How to Cite
1.
Mytsyk Y. 2019-NCOV PANDEMIC: IMPACT ON REPRODUCTIVE HEALTH. Proc Shevchenko Sci Soc Med Sci [Internet]. 2020Apr.15 [cited 2020Aug.15];59(1). Available from: https://mspsss.org.ua/index.php/journal/article/view/283