SYNDROME OF LOW TOLERANCE TO HISTAMINE: VALUE FOR PRACTICAL MEDICINE

  • Svitlana Zubchenko Львівський національний університет імені Данила Галицького, кафедра клінічної імунології та алергології, Львів, Україна
  • Maria Mazur Львівська міська лікарня №1 імені Князя Лева, Львів, Україна
  • Sergiy Yuriev Українська школа молекулярної алергології та імунології, Київ,Україна
  • Stepan Marunyak Львівський національний університет імені Данила Галицького, кафедра клінічної імунології та алергології, Львів, Україна
Keywords: histamine, diamine oxidase, syndrome of histamine intolerance, diagnostic

Abstract

Histamine – biogenic amine that is synthesized in the human body and acts as a mediator of a number of biological reactions. The extracellular histamine pathway involving enzymes diamine oxidase. Lack activity of this enzyme leads to a syndrome of histamine intolerance and out comes related to the pleiotropic effects of histamine. The article presents the main causes of decreased activity diamine oxidase, typical clinical symptoms that characterize this syndrome, diagnostical go rithm and characteristics of patients. Described as analternative, safe for patient test for diagnosing the syndrome of histamine intolerance – «Histamin 50-Skin- Prick Test». Based on the clinical cases shows modern diagnostic capabilities in specifi c patients with manifestations of allergic pathology. Understanding the pathogenesis of the syndrome of histamine intolerance, research in to the diagnosis of failure diamine oxidase gives opportunities to the choice of effective approaches in the treatment of patients so requires a deep knowledge of physicians of differents pecialties.

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Published
2016-11-16
How to Cite
1.
Zubchenko S, Mazur M, Yuriev S, Marunyak S. SYNDROME OF LOW TOLERANCE TO HISTAMINE: VALUE FOR PRACTICAL MEDICINE. Proc Shevchenko Sci Soc Med Sci [Internet]. 2016Nov.16 [cited 2021Feb.26];47(2):34-0. Available from: https://mspsss.org.ua/index.php/journal/article/view/26