Keywords: thyroid, lymphocytic infiltrates, lymphoid follicles, focal thyroiditis, autoimmune Hashimoto’s thyroiditis, thyroid papillary carcinoma


Introduction. The pathohistological examination of the surgical material of patients operated on for thyroid disease reveals in the thyroid gland a diff erent degree of lymphocyte accumulation: lymphoid follicles, focal and diff use lymphocytic infi ltrates.
Methods. With aim to determine the composition and features of the localization of lymphocytic infi ltrates in thyroid gland a typical pathohistological and immunohistochemical examination of surgical material of 15 patients operated on for autoimmune Hashimoto’s thyroiditis, focal thyroiditis and thyroid papillary carcinoma in combination with autoimmune or focal thyroiditis using antibodies to the lymphocytes antigens CD3, CD8, CD20 and CD138 was made.
Results and conclusions. In Hashimoto’s autoimmune thyroiditis and focal thyroiditis CD3 and CD8 positive lymphocytes equally in T-dependent zones and CD20 positive lymphocytes in B-dependent zones of lymphoid follicles were found. In patients with thyroid papillary carcinoma in the tumor and adjacent to the tumor tissue of the thyroid gland moderate infi ltration of CD3 and CD8 positive lymphocytes were revealed. The same composition of lymphoid follicles in Hashimoto’s autoimmune thyroiditis and focal thyroiditis is an additional argument in favor of the fact that these two diseases are diff erent stages in the development of a single autoimmune lesion. The presence of CD8 positive lymphocytes in the tumor in thyroid papillary carcinoma is a manifestation of the local immune response and is of great clinical and prognostic importance.


Download data is not yet available.


An JL, Ji QH, An JJ, Masuda S, Tsuneyama K. Clinicopathological analysis of CD8-positive lymphocytes in the tumor parenchyma and stroma of hepatocellular carcinoma. Oncol Lett. 2014;8(5):2284-2290.

Ashton-Key M, Wright D, Wright D. Diagnostic lymph node pathology. 3rd edition. CRC Press, 2018. 216 p.

Borowczyk M, Janicki A, Dworacki G, Szczepanek-Parulska E, Danieluk M, BarnettJ, Antonik M, Kałużna

M, Bromińska B, Czepczyński R, Bączyk M, Ziemnicka K,Ruchała M. Decreased staging of diff erentiated

thyroid cancer in patients with chronic lymphocytic thyroiditis. J Endocrinol Invest. 2019 Jan;42(1):45-52.

Chernenko OV, Sulaeva OM, Chuba VY, Ohryz'ko TV, Larin OS. Rol' makrophagiv u progresuvanni

papilarnoro raku schytopodibnoj zalozy. Ukrainskyj zhurnal medycyny, biologii i sportu. 2018;6(15):188-192.

Ehlers M, Schott M. Hashimoto's thyroiditis and papillary thyroid cancer: are they immunologically linked? Trends Endocrinol Metab. 2014; 25(12):656-64.

Ferrari SM, Fallahi P, Elia G, Ragusa F, Ruffi lli I, Paparo SR, Antonelli A. Thyroid autoimmune

disorders and cancer. Semin Cancer Biol. 2019 May 31. pii:S1044-579X(18)30159-7. doi: 10.1016/j.


Graceff a G, Patrone R, Vieni S, Campanella S, Calamia S, Laise I, Conzo G,Latteri M, Cipolla C.

Association between Hashimoto's thyroiditis and papillary thyroid carcinoma: a retrospective analysis

of 305 patients. BMC Endocr Disord.2019 May 29;19(Suppl 1):26. doi: 10.1186/s12902-019-0351-x.

Harach HR, Ceballos GA. Thyroid cancer, thyroiditis and dietary iodine: a review based on the Salta,

Argentina model. Endocr Pathol. 2008; 19(4):209-220.

Harach HR, Williams ED. Thyroid cancer and thyroiditis in the goitrous region of Salta, Argentina, before

and after iodine prophylaxis. Clin Endocrinol (Oxf). 1995; 43(6):701-706.

Lai X, Xia Y, Zhang B, Li J, Jiang Y. A meta-analysis of Hashimoto's thyroiditis and papillary thyroid

carcinoma risk. Oncotarget. 2017; 8(37):62414-62424.

Laugel B, Cole DK, Clement M, Wooldridge L, Price DA, Sewell AK. The multiple roles of the CD8

coreceptor in T cell biology: opportunities for the selective modulation of self-reactive cytotoxic T cells.

J Leukoc Biol. 2011; 90(6):1089-1099.

Mills SE. Histology for pathologists. 4th Edition. Philadelphia, Baltimore, New York, London, Buenos

Aires, Hong Kong, Sydney, Tokyo: Wolters Kluwer Lippincott Williams & Wilkins, 2012. 1328 p.

Moon S, Chung HS, Yu JM, Yoo HJ, Park JH, Kim DS et al. Associations between Hashimoto thyroiditis

and clinical outcomes of papillary thyroid cancer: A meta-analysis of observational studies. Endocrinol

Metab (Seoul). 2018; 33(4):473-484.

Nicolson NG, Brown TC, Korah R, Carling T. Immune cell infi ltrate-associated dysregulation of DNA

repair machinery may predispose to papillary thyroid carcinogenesis. Surgery. 2020; 167(1):66-72.

Peng GL, Li L, Guo YW, Yu P, Yin XJ, Wang S et al. CD8+ cytotoxic and FoxP3+ regulatory T lymphocytes

serve as prognostic factors in breast cancer. Am J Transl Res. 2019;11(8):5039-5053.

Pessôa-Pereira D, Medeiros MFDS, Lima VMS, Silva JCDJr, Cerqueira TLO, Silva ICD, Fonseca LEJr,

Sampaio LJL, Lima CRA, Ramos HE. Association between BRAF(V600E) mutation and clinicopathological

features of papillary thyroid carcinoma: a Brazilian single-centre case series. Arch Endocrinol Metab. 2019 Mar-Apr;63(2):97-106. doi: 10.20945/2359-3997000000120.

Resende de Paiva C, Grønhøj C, Feldt-Rasmussen U, von Buchwald C. Association between Hashimoto's

thyroiditis and thyroid cancer in 64,628 patients. Front Oncol. 2017;7:53. doi: 10.3389/fonc.2017.00053.

eCollection 2017.

Rhoden KJ, Unger K, Salvatore G, Yilmaz Y, Vovk V, Chiappetta G, Qumsiyeh MB, Rothstein JL, Fusco

A, Santoro M, Zitzelsberger H, Tallini G. RET/papillary thyroid cancer rearrangement in nonneoplastic

thyrocytes: follicular cells of Hashimoto's thyroiditis share low-level recombination events with a subset

of papillary carcinoma. J Clin Endocrinol Metab. 2006; 91(6):2414-2423.

Schmidt N, Flecken T, Thimme R. Tumor-associated antigen specifi c CD8+ T cells in hepatocellular

carcinoma - a promising target for immunotherapy. Oncoimmunology. 2014; 3(9):e954919.

Vita R, Ieni A, Tuccari G, Benvenga S. The increasing prevalence of chronic lymphocytic thyroiditis in

papillary microcarcinoma. Rev Endocr Metab Disord.2018 Dec;19(4):301-309. doi: 10.1007/s11154-018-9474-z.

Vovk VI, Omelyash UV. Papilarnyi rak ta avtoimunnyi thyreoidyt Hashimoto u chvorych, operovanych z pryvody zachvoriuvan' schytopodibnoj zalozy v umovach Prykarpatskoho endemichnoho regionu zoba.

Morphologia. 2019; 13(3):22-25.

Abstract views: 145
PDF Downloads: 68
How to Cite
Vovk V, Omelyash U. LYMPHOCYTAR INFILTRATES IN THE THYROID GLAND OF PATIENTS OPERATED ON THE BASIS OF THYROID PATHOLOGY. Proc Shevchenko Sci Soc Med Sci [Internet]. 2019Dec.24 [cited 2021Sep.18];57(2). Available from: