LYMPHOCYTAR INFILTRATES IN THE THYROID GLAND OF PATIENTS OPERATED ON THE BASIS OF THYROID PATHOLOGY

Keywords: thyroid, lymphocytic infiltrates, lymphoid follicles, focal thyroiditis, autoimmune Hashimoto’s thyroiditis, thyroid papillary carcinoma

Abstract

Introduction. The pathohistological examination of the surgical material of patients operated on for thyroid disease reveals in the thyroid gland a diff erent degree of lymphocyte accumulation: lymphoid follicles, focal and diff use lymphocytic infi ltrates.
Methods. With aim to determine the composition and features of the localization of lymphocytic infi ltrates in thyroid gland a typical pathohistological and immunohistochemical examination of surgical material of 15 patients operated on for autoimmune Hashimoto’s thyroiditis, focal thyroiditis and thyroid papillary carcinoma in combination with autoimmune or focal thyroiditis using antibodies to the lymphocytes antigens CD3, CD8, CD20 and CD138 was made.
Results and conclusions. In Hashimoto’s autoimmune thyroiditis and focal thyroiditis CD3 and CD8 positive lymphocytes equally in T-dependent zones and CD20 positive lymphocytes in B-dependent zones of lymphoid follicles were found. In patients with thyroid papillary carcinoma in the tumor and adjacent to the tumor tissue of the thyroid gland moderate infi ltration of CD3 and CD8 positive lymphocytes were revealed. The same composition of lymphoid follicles in Hashimoto’s autoimmune thyroiditis and focal thyroiditis is an additional argument in favor of the fact that these two diseases are diff erent stages in the development of a single autoimmune lesion. The presence of CD8 positive lymphocytes in the tumor in thyroid papillary carcinoma is a manifestation of the local immune response and is of great clinical and prognostic importance.

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Published
2019-12-24
How to Cite
1.
Vovk V, Omelyash U. LYMPHOCYTAR INFILTRATES IN THE THYROID GLAND OF PATIENTS OPERATED ON THE BASIS OF THYROID PATHOLOGY. Proc Shevchenko Sci Soc Med Sci [Internet]. 2019Dec.24 [cited 2021Sep.18];57(2). Available from: https://mspsss.org.ua/index.php/journal/article/view/234