PROBLEMS OF VERIFI CATION OF HEMATOLOGICAL NEOPLASMS ASSOCIATED WITH CHORNOBYL RADIATION DISASTER: CASE-BASED REVIEW

Keywords: hematologic malignancies, non-Hodgkin’s lymphoma, radiation-induced neoplasms, nuclear reactor accidents

Abstract

Introduction.The elucidation of the impact of radioactive contamination caused by the Chornobyl accident on the development of neoplasms of hematogenous origin remains an actual problem. Therefore, the assessment of cancer incidence due to contamination of large territories by radionuclides should be based not only on epidemiological data, but also by taking into account the individual clinical cases of these diseases as a consequence not only of deterministic but also stochastic eff ects.

The aim of our study was to analyze clinical cases of hematopoietic and lymphoid cell tumors associated with the Chornobyl accident. To detect hematologic neoplasms caused by radiation and elaborate criteria for their diff erentiation with spontaneous morbidity.

Objectives. Retrospective analysis of available medical records of patients with hematologic neoplasms living or lived in the Lviv region, whose tumors may be associated with the Chornobyl accident, during the 25-year period from 1992 to 2017.

Results. We found that the information about offi cially registered cases of hematologic neoplasms in persons recognized as victims of the Chornobyl accident, fi rst of all those who participated in the elimination of the consequences of the accident, their children and displaced persons, remains closed. Only in six cases we were able to make a retrospective analysis of medical records of persons with hematologic neoplasms associated with the Chornobyl accident. Five of these patients are children of liquidators and one person was resettled from Kyiv region. The disease was diagnosed in childhood in four cases and in young age in two
cases (21 and 25 years old). It was diagnosed non-Hodgkin’s lymphoma in four patients, Hodgkin’s disease in one and acute myeloblastic leukemia in one patient. Based on the analysis, a clinical case of non-Hodgkin’s lymphoma, most likely associated with the Chornobyl accident, was described. The paper analyzes the problems of detecting tumors caused by radionuclide contamination as a result of the Chornobyl accident.

Conclusion. Cases of neoplasms that may be associated with the Chernobyl disaster require a comprehensive analysis, long-term follow-up of patients and reporting in scientifi c publications.

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2019-12-24
How to Cite
1.
Dzis Y, Tomashevska O. PROBLEMS OF VERIFI CATION OF HEMATOLOGICAL NEOPLASMS ASSOCIATED WITH CHORNOBYL RADIATION DISASTER: CASE-BASED REVIEW. Proc Shevchenko Sci Soc Med Sci [Internet]. 2019Dec.24 [cited 2021Sep.18];57(2). Available from: https://mspsss.org.ua/index.php/journal/article/view/225