Keywords: herpes simplex infection, connective tissue disease, clinical manifestation, antiviral and immunotropic therapy


Introduction. Considering the importance of herpes simplex virus infection as one of the triggers in the development of systemic connective tissue diseases, studying and evaluating the eff ectiveness of antiviral treatment is an important issue in this group of patients.
Aim. The investigation of clinical effi cacy of antiviral therapy in patients with systemic connective tissue disease and chronic recurrent herpes during and after treatment and in the long term, depending on the therapy received.
Materials and methods. The study involved 59 patients who were treated at Lviv Regional Clinical Diagnostic Center and Lviv Regional Clinical Hospital - clinical centres of the Department of Clinical Immunology and Allergology of Danylo Halytsky Lviv National Medical University.
Results. Based on the data obtained, the clinical effi cacy of Inosine pranobex (Novirini) in groups of patients with mild, moderate and severe herpes simplex infection and systemic connective tissue disease was calculated. The results show that use of Inosine Pranobex in patients with a mild course HSV 1/2 infection contributed to headache relief in 82.4%, temperature normalization in 75.0%, and decreases fatigue in 72.2%. In the group of patients with moderate to severe herpes virus infection, who received Acyclovir in addition to Inosine Pranobex, headache was reduced in 73.9%, temperature normalization in 66.6%, fatigue reduction in 65.5% of cases.
Conclusion. The use of antiviral therapy in patients with systemic connective tissue disease and recurrent herpes simplex virus infection had a positive eff ect on patients' general condition, which was manifested by reduced intensity and frequency of headaches, the severity of fatigue and normalization of body temperature in all patients. Therefore, we can recommend antiviral therapy for this group of patients as part of the complex therapy involving an individual approach to each patient, which presupposes personalized treatment.


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Horbal N. PECULIARITIES OF OF IMMUNOLOGICAL PARAMETERS IN PATIENTS WITH RECURRENT HERPES SIMPLEX VIRUS INFECTION. Proc Shevchenko Sci Soc Med Sci [Internet]. 2019Dec.24 [cited 2021Sep.18];57(2). Available from: