DRUG FLURENISID AS AN IMMUNOMODULATOR FOR THE TREATMENT OF ORPHAN DISEASES

  • Мaria Kovalenko Danylo Halytsky Lviv National Medical University, Lviv, Ukraine
Keywords: medicinal product (drug), fl uorenic, viral infections, rare (orphan ) diseases

Abstract

Flurenizide was created as a result of purposeful synthesis of fl uorene series compounds and research into their chemical, physical, biological and pharmacological characteristics. The study was directed at converting low-molecular chemical compounds into medication according to the following scheme: «biologically active substance → pharmacological compound → medication». The further task was to turn the idea into reality and create a new effective medication. It was necessary to consistently go through a long way, which includes related disciplines «science → technology → production → pharmacology → medicine → treatment standards». Based on biological studies in vitro and in vivo, antimicrobial and antiviral effects of Flurenizide and others new fl uorenes were detected on different strains of microorganisms and types of viruses. Preclinical pharmacological and experimental clinical trials of Flurenizide were made owing to close scientifi c collabo-ration between scientists from research laboratories members of medical institutions departments, research and production enterprises etc. Basic aspects: • extensive preclinical and clinical investigation of new biologically active compounds of fl uorene series as a promising chemotherapeutic products for medicine and veterinary medicine. • microbiological, pharmacological, pharmaco-technological and clinical study of antituberculous, anti-chlamidia, antimicrobial, immunomodulating and antiviral Flurenizide medication and farmaceutical forms based on it. Flurenizide is introduced into Ukrainian production standards and standards in healthcare institutions of medicosanitary help. Based on an innovative product – an original Ukrainian substance of Flurenizide, promising dosage forms for different branches of medicine was created. Owing to joint efforts, worthy contributions were made to the development of Ukrainian pharmaceutical and medical science, to domestic production of effective and safe medicines. Flurenizide (code G01A X) is available in the project «Reference list of preparations that could be used to prove the equivalence of medications». Flurenisid – preparation of a new class (class fl uorene) is proposed for use in the treatment of viral infections, immunodefi ciencies and rare diseases.

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2017-12-29
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1.
KovalenkoМ. DRUG FLURENISID AS AN IMMUNOMODULATOR FOR THE TREATMENT OF ORPHAN DISEASES. Proc Shevchenko Sci Soc Med Sci [Internet]. 2017Dec.29 [cited 2022Jul.2];50(2):75-4. Available from: https://mspsss.org.ua/index.php/journal/article/view/109