FUNDAMENTAL AND APPLIED LECTINOLOGY: CONTRIBUTION OF LVIV SCIENTISTS (1972-2017) DEDICATED TO 75TH BIRTH ANNIVERSARY OF MAXYM D. LUTSIK – LVIV LECTINOLOGISTS TEAM FOUNDER

  • Alexander Lutsyk Danylo Halytskyi Lviv National Medical University
  • Antonina Yashchenko Institute of Cell Biology, NAS Ukraine
  • Volodymyr Antonyuk Danylo Halytskyi Lviv National Medical University
  • Rostyslav Bilyy Institute of Cell Biology, NAS Ukraine,
Keywords: Lviv scientifi c school of lectinologists, glycopolimers, lectins, biobibliography

Abstract

The formation and development of the Lviv scientifi c team of lectinologists during 35 years (1972- 2017) is described. During this period were substantially optimized methods of lectin purifi cation, and about 20 new original lectin preparations were purifi ed and characterized. Remodeling of lectin-reactive glycopolymers in the process of embryonic and postnatal ontogenesis of different organs, as well as their transformation due to the development of various forms of experimental and clinical pathology have been investigated. Were revealed new possibilities of lectins application as selective histochemical markers of certain types of cells; heterogeneity of lectins binding to cellular subpopulations depending on their organ specifi city, degree of differentiation, secretory cycle cycle; use of lectins for the characterization of cellular glycosylation processes under physiological and pathological conditions, in particular, on the background of experimental hypo- and hyperthyroidism. The prospects of application in histochemistry of a number of new original lectin preparations were demonstrated. There were expanded existing viewers on the role of cell surface glycoconjugates in the intercellular interactions and in the process of apoptotic transformations; the role of glycans in ensuring the interaction of pathogens with host cells, in particular, of the adherent-invasive E.coli bacteria with cells of the epithelial series, as well as the immune cells (neutrophils, monocytes) of the host’s organism; the effect of neutrophils activation on the modifi cation of glycane components of adjusting molecules, with specifi c emphasis on the molecules of immunoglobulins involved in infl ammatory processes. On the basis of accomplished research were published 5 monographs, about 200 articles in the leading national and internationally renowned journals, as well as 7 author certifi cates and patents were received. 5 DSci and 14 PhD theses were conferred. Qualifi ed counseling and lectin preparations were provided for the implementation in about 30 PhD and DSci dissertations for researchers of Lviv Medical University, other Ukrainian and foreign universities. A bibliographic list of the most important publications of Lviv lectinologists is accomplished.

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Lutsik MD. A new affinity sorbent for the purification of lectins and its use in the purification of wheat germ agglutinin. Ukr Biokhimicheskii Zhurnal, 1978, 56(4): 432–436 (Russian).

Lutsik MD, Kusen SI. Study of membrane glycoproteins of human erythrocytes using lectins. Ukr Biokhimicheskii Zhurnal, 1978, 59(6): 3–9 (Russian).

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Lutsyk AD, Zerbino DD, Kotyk AE, Havriliuk EM, Dmitruk IM. Dissecting aortic aneurism: histochemical investigation using a set of lectins with different carbohydrate specificities. Аrch Pathol. 1987, 49(3): 20-24 (Russian).

Lutsyk AD, Yashchenko AM, Detiuk ES. Influence of thyroid hormones on the histotopography of lectin receptors in the salivary glands of a rat. Bull Exp Biol Med. 1987, 103(4): 492-495 (Russian).

Lutsyk AD, Dmitruk IM, Zerbino DD. Lectin receptors in transitional cell neoplasia of urinary Vopr Onkol. 1987, 33(4): 60-65 (Russian).

Lutsyk AD, Detiuk ES. Lectin’s application in light optic histochemistry (methodological aspects). Arkh Anat Gistol Embriol. 1987, 92(6): 74-89 (Russian).

Lutsyk AD, Zerbino DD. Use of lectins in pathomorphology: the results and prospects. Arch Pathol. 1988, 50(3): 77-82 (Russian).

Lutsyk AD. Lectins as a selective histochemical markers of certain cell types and their subpopulations, extracellular tissue structures. Arkh Anat Gistol Embriol. 1988, 95(11): 83-104 (Russian).

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Karaganov IL, Lutsik MD, Mironov VA, Mironov AA. Labeled lectins in the study of cell surfaces. Arkh Anat Gistol Embriol. 1986, 90(3): 83–94 (Russian).

Khomutovskii OA, Lutsik MD, Perederei OF, Pogorelaia NK, Chubchenko SI. Localization of lectin receptors on the surface of C1300 neuroblastoma cells. Eksp Onkol. 1986, 8(4): 41–45 (Russian).

Koval’ LM, Skibo GG, Lutsik MD. Study of the distribution of surface membrane glycoconjugates in spinal cord and spinal ganglia neurons cultured in a Dokl Akad Nauk SSSR, 1988, 303(2): 481–483 (Russian).

Gluzman DF, Skliarenko LM, Lutsik MD. Lectin receptors – histochemical markers in the study of leukemias and lymphomas. Eksp Onkol. 1988, 10(6): 9–16 (Russian).

Skibo GG, Koval’ LM, Lutsik MD. Electron cytochemical detection of carbohydrate determinants of surface membrane of cultured neurons. Dokl Akad Nauk SSSR, 1988, 300(4): 971–973 (Russian).

Iarilin AA, Nikonova MF, Lutsik MD. The relation of changes in the surface markers and the induction of thymocyte functional activity under the action of humoral thymic factors. Tsitologiia, 1989, 31(8): 945–954 (Russian).

Tsegel’skii AA, Lutsik MD, Lashkai Study of the carbohydrate components of the surface of S 1300 neuroblastoma cells with the use of cytochemical and lectin agglutination methods. Eksp Onkol. 1989, 11(5): 30–34 (Russian).

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Lutsyk AD, Yashchenko AM, Detiuk ES. Comparative histochemical study of glycoconjugates of human large salivary glands and pancreas. Arkh Anat Gistol Embriol. 1989, 97(7): 70-80 (Russian).

Lutsyk AD, Yatskovsky Use of lectin histochemistry methods for the characterization of biopolymer glycosylation processes in duodenal gland cells. Bull Exp Biol Med. 1990, 110(10): 440-444 (Russian).

Yatskovsky AN, Lutsyk Comparative lectin histochemical analysis of the duodenal glands in various mammals. Arkh Anat Gistol Embriol. 1991, 100(2): 61-69 (Russian).

Lutsyk AD, Lutsyk BD, Stekhnovich Lectin histochemistry of human cerebral microglia in bacterial meningoencephalitis. Zhurnal Neurol Psychiatr. 1991, 91(2): 41-44 (Russian).

Lutsyk AD, Yashchenko AM, Detiuk Lectin histochemistry of human placenta in the normal state and in uterine inertia. Arkh Anat Gistol Embriol. 1991, 100(4): 9-14 (Russian).

Lutsyk AD, Kotyk AE, Zerbino DD. Accumulation of abnormal glycopolymers in the wall of the main lymphatic of human limbs in chronic Bull Exp Biol Med. 1991, 111(4): 414-417 (Russian).

Lutsyk AD, Lutsyk BD, Yashchenko Lectin-peroxidase markers of microglia in paraffin sections. Arkh Pathol. 1991, 53(4): 60-63 (Russian).

Yatskovsky AN, Boronikhina TV, Sukhanov BP, Lutsyk AD. Changes in the duodenal glands with a mod- ification of diet: a histochemical study using lectins. Morfologiia, 1993, 104(3-4): 112-119 (Russian).

Yatskovsky AN, Boronikhina TV, Lutsyk Duodenal glands of representatives of insectivores and pri- mates. Morfologiia, 1994, 105(1-3): 94-103 (Russian).

Shapovalova EYu, Zabashta TI, Lutsyk AD. Receptors of lectins in the early histogenesis of epithelial and mesenchymal derivatives of the primary oral cavity in humans. Tavricheskii Mediko-Biologicheskii Vestnik, 1999, 1-2: 45-48 (Russian).

Yashchenko LM, Besedin VM, Lutsyk AD. Glycoconjugates of placenta and decidual membrane of childbirth women with late gestoses as detected by lectin histochemistry. Acta Medica Leopoliensia 2000, 6(1): 79-84 (Ukrainian).

Shapovalova EYu, Georgievskaya LS, Zabashta TI, Lutsyk AD. Modern aspects of intercellular interac- tions in the glandular stage of lung Visnyk Morphologii, 2000, 6(1): 150-152 (Ukrainian).

Shapovalova EYu, Georgievskaya LS, Zabashta TI, Lutsyk Organo-specific histochemical and lectin histochemical features of embryonic histogenesis of tracheal hyaline cartilage in humans. Orthopaediia Traumatologiia Protezirovaniye, 2000, 2: 46-49 (Russian).

Degtiariova LV, Kozlova TP, Lutsyk AD. Redistribution of lectin receptors in the mucousal membrane of stomach and duodenum of Chornobyl accident liquidators affected by ulcerative disease. Acta Medica Leopoliensia, 2000, 6(3): 23-31 (Ukrainian).

Shapovalova EYu, Lutsyk AD. Changes in the carbohydrate composition of tissues during early embry- ogenesis of human respiratory system. Tavricheskii Mediko-Biologicheskii Vestnik, 2000, 3(1-2): 135- 138 (Russian).

Smolkova OV, Zavadka AE, Bankston PW, Lutsyk Cellular heterogeneity of rat vascular endothelium as detected by HPA and GS I lectin-gold probes. Medical Science Monitor, 2001, 7(4): 659-668.

Stoika BR, Lutsyk AD. Immunocytochemical aspects of male Acta Medica Leopoliensia 2002; 8(2): 52-60 (Ukrainian).

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Stoika BR, Yashchenko AM, Fitio YuS, Lutsyk AD. Lectin histochemical investigation of sperm cells in human couple Acta Medica Leopoliensia 2003, 9(2): 69-74 (Ukrainian).

Yashchenko AM, Stoika BR, Smolkova OV, Nakonechna OV, Lutsyk Hypothetical role of lectin recep- tors as markers of apoptosis in testicular cells under thyroid pathology. Tavricheskii Mediko- Biologich- eskii Zhurnal 2003, 6(3): 153-155 (Ukrainian).

Antonyuk VO, Yashchenko AM, Lutsyk AD. Comparative biochemical characteristics and binding selec- tivity of fucose-specific lectins from perch (Persa fluviatilis L.) and Laburnum anagyroides Medik. Acta Medica Leopoliensia, 2004, 10 (1): 62-70 (Ukrainian).

Stoika BR, Domagala A, Kamienichna M, Kurpish M, Nadiuk ZO, Gelner NV, Zastavna DV, Stoika RS, Lutsyk AD. Exposure of sperm antigens and antispermal antibodies: an immunocytochemical study in males with impairments of fertile function and in Chernobyl accident affected patients with diagnosed autoimmune thyroiditis. Acta Medica Leopoliensia, 2004, 10(3-4): 46-53 (Ukrainian).

Loginskyy VYe, Shalaj OO. Lectin binding carbohydrate components of blast cells in acute myeloid leucosis. Onkologiia, 2004, 6(3): 231-235 (Ukrainian).

Loginskyy VYe, Shalaj OO. Glycan structures of lymphocyte membranes in patients with chronic lymphoid leukemia. Onkologiia, 2005, 7(1): 19-22 (Ukrainian).

Antonyuk VO, Yashchenko AM, Lutsyk AD. Lectins from bark of Laburnum аnagyroides : binding to carbohydrates and application in histochemical research. Acta Medica Leopoliensia, 2004, 10(3-4): 54-59 (Ukrainian).

Antonyuk VO, Lutsik MD. Influence of vegetation phase of plants on the activity of lectins, specific to D-galactose group carbohydrates. Ukr Botanichnyi Zhurnal, 1986, 43(4): 21-25 (Ukrainian).

Antonyuk Application of mannofucogalactan from Phellinus igniarius (L:Fr.) Quell for the purification of lectin fromAleuria aurantia (Fr.) Tekl. Micologiia i Fitopatologiia, 1990, 24(6): 538-542 (Russian).

Antonyuk VA. Lectins from Polygonatum multiflorum (L.) All. Purification, properties and preparation of peroxidase and colloidal gold labeled derivatives. Biokhimiia, 1992, 57(12): 1847- 1854 (Russian).

Antonyuk VO. Purification and properties of lectins from Polygonatum multiflorum (L.) All. and Polygo- natum verticillatum (L.) All. Ukr Biokhimichnyi Zhurnal, 1993, 65(1): 41- 48 (Ukrainian).

Antonyuk LYa, Antonyuk Interaction of spring snow-white lectin with polysaccharides and glycopro- teins. Ukr Biokhimichnyi Zhurnal, 1993, 65(5): 69-73 (Ukrainian).

Lutsik MD, Antoniuk Preparation of an anti-A reagent from the lectin of hairy vetch (Vicia villosa) for detecting antigen A in human erythrocytes and saliva. Sud Med Ekspert. 1995, 38(1): 17–9 (Russian).

Antonyuk VO. Purification of lectin from Paris quadrifolia L. and comparison of its carbohydrate speci- ficity with some other lectins from plants of Liliaceae Ukr Biokhimichnyi Zhurnal, 1996, 68(6): 86-91 (Ukrainian).

Antonyuk Purification and partial characterization of fucose-specific lectin from fruiting bodies of Peziza badia Merat. Biokhimiia, 1997, 62(8): 983-987 (Russian).

Antonyuk Characterization of fucose-specific lectins from fruiting bodies of Peziza badia Merat. and Peziza verticulosa St. Am. Ukr Botanichnyi Zhurnal, 1998, 55(3): 269-274 (Ukrainian).

Antonyuk VO, Antonyuk Preparation of phytin and lectin from wheat germs in one technological cycle. Ukr Biokhimichnyi Zhurnal, 2000, 72(2): 97-99 (Ukrainian).

Antonyuk Purification of cellobiose-specific lectin from perch (Perca fluviatilis L.) roe and investigation of its properties. Ukr Biochimichnyi Zhurnal, 2004, 76(1): 72-77 (Ukrainian).

Antonyuk L-fucose-specific lectin from roe of pike perch (Lucioperca lucioperca L.): purification and investigation of carbohydrate specificity. Ukr Biochimichnyi Zhurnal, 2004, 76(2): 60-64 (Ukrainian).

Antonyuk VO. Investigation of carbohydrate specificity of haemolytic lectin from Amanita phalloides (Vaill. )Secr ). Biopolymers and Cell, 2005, 21(4): 1-7 (Ukrainian).

Antonyuk RV, Antonyuk VO. Potato beetle. Influence of lectins on the development of larvae pest. Karantyn i Zachyst Roslyn, 2006, 12: 16-17 (Ukrainian).

Antonyuk Investigation on the interaction of hederosaponin with lectins. Farmacevtychnyi Zhurnal, 2007, 2: 84-88 (Ukrainian).

Antonyuk Investigation on the interaction of ristomycin sulfate with lectins. Visnyk Farmacii, 2008, 52(3): 73-79 (Ukrainian).

Antonyuk VO, Yashchenko AM, Antonyuk RV, Ambarova NO. Carbohydrate specificity of lectin purified from the fruiting bodies of Mycena pura /Fr./ Kumm. and its application in histochemical research. Biopolimers and Cell, 2009, 25(6): 466-475 (Ukrainian).

Panchak LV, Antonyuk Purification of lectin from fruiting bodies of Lactarius pergamenus (Fr.)Fr and investigation of its properties. Biokhimiia, 2011, 76(4): 537–550 (Russian).

Antonyuk VО, Klyuchivska OYu , Stoika RS. Cytotoxic proteins of Amanita virosa Secr. mushroom: pu- rification, characteristics and action towards mammalian cells. Toxicon, 2010, 55: 1297 -1305.

Antonyuk VO, Panchak LV, Starikovich MO, Stoika New mannose-specific lectin from rhizoma of Hem- erocallis fulva L.: purification and properties. Ukr Biokhimichnyi Zhurnal, 2013, 2: 27-32 (Ukrainian).

Antonyuk VO, Panchak LV, Starikovich MO, Strutovska RS, Stoika RS. Purification and characterization of new mannose-specific lectin from bulbs of Hyacinthella acutiloba K. Perss. Biotechnologica Acta, 2013, 6(3): 69-74.

https://doi.org/10.15407/biotech6.03.069

Antonyuk VO. Lectins: distribution and function in living organisms, peculiaritiesof raw materials pro- curement. Ukr Biofarmacevtychnyi Zhurnal, 2013, 6: 4 -10 (Ukrainian).

Antonyuk VO. Complex use of artichoke tubers: purification of inulin, fructose and mannose-specific lectin. Farmacevtychnyi Zhurnal 2014, 3: 50-60 (Ukrainian).

Zayachkivska OS, Lutsyk DA, Yashchenko AM, Dzhura OR, Lutsyk AD. Expression of lectin receptors in the gastrointestinal mucosa during stress-induced lesions and melatonin correction. Tavricheskij Medi- co-Biologicheskii Vestnik, 2006, 9(3): 67-70 (Russian).

Dzura OR, Yashchenko AM, Antonyuk VO, Lutsyk AD. Lectin histochemistry of parathyroid glands of human males and females in the age-related aspect. Acta Medica Leopoliensia, 2006, 12(1): 12-17 (Ukrainian).

Kostiukova OA, Burlak NP, Dzura OR, Yashchenko AM. Cytotopography of lectin receptors in duodenal mucosa at ulcerative disease. Experimental Clinical Physiology Biochemistry, 2007, 37(2): 44-53 (Ukrainian).

Yashchenko AM, Dzhura OR, Lutsyk AD. Expression of lectin receptors during osteogenesis of long bones in guinea pigs. Svit Medycyny Biologii, 2007, 3: 45-53 (Ukrainian).

Ambarova NO, Lutsyk AD. Binding of lectins with different carbohydrate specificities to glycopolymers of neonatal rats kidneys. Acta Medica Leopoliensia, 2007, 13(4): 59-66 (Ukrainian).

Yashchenko AM, Balush LV, Lutsyk AD. Lectin histochemistry of rat liver in streptozotocin-induced diabetes mellitus. Visnyk Morfologii, 2008, 14(1): 240-245 (Ukrainian).

Ambarova NO, Antonyuk RV, Lutsyk AD. Redistribution of rat kidney mannosoglycans in postnatal ontogenesis and in streptozotocin-induced diabetes mellitus. Svit Medycyny Biologii, 2008, 4: 95-103 (Ukrainian).

Ambarova NO, Antonyuk VO, Lutsyk AD. Rat kidney fucosoglycans: redistribution in postnatal ontogenesis and during development of streptozotocin-induced diabetes mellitus. Klinichna Anatomiia Operatyvna Hirurgiia, 2009, 8(1): 15-21 (Ukrainian).

Balush LV, Yashchenko AM, Lutsyk Histochemical and electron microscopic investigation of pancreas in experimental diabetes mellitus. Klinichna Anatomiia Operatyvna Hirurgiia, 2009, 8(1): 37-43 (Ukrainian).

Lutsyk AD, Sogomonian Histology and lectin histochemistry of rat ovaries under experimental hypo- and hyperthyroidism. Svit Medycyny Biologii, 2009, 2: 116-124 (Ukrainian).

Kharkovenko RV, Pushkar MS, Yashchenko Lectin histochemistry of retina and optic nerve in normal conditions and under hyperhomocysteinemia. Svit Medycyny Biologii, 2009, 3: 173-179 (Ukrainian).

Radchuk OM, Beregova TV, Yashchenko AM, Rybalchenko VK. Cytotopography of lectin receptors in colonic mucosa under the influence of «Omeza» and multyprobiotic «Sembiter acidophilic». Morphologiia, 2009, 3(4): 71-78 (Russian).

Sogomonyan EA, Lutsyk AD. Micromorphology and redistribution of lectin receptor sites in rat endometrium under experimental hypo- and Klinichna Anatomiia Operatyvna Hirurgi- ia, 2010, 9(3): 58-64 (Ukrainian).

Lutsik MM, Yashchenko AM, Kovalyshyn VI, Prydatko OE, Stoika RS, Lutsik MD. Heterogeneity of cell population of lymphoma NK/Ly and leukemia L-1210 according to carbohydrate structure of cell sur- face: immunocytochemical analysis of lectin Tsitologija Genetica, 2011, 45(2): 3–9 (Russian).

Falaleyeva TM, Beregova TV, Samogina GE, Yashchenko AM. Specificity of carbohydrate componets of gastric mucosa glycoprotein receptors after prophylactic administration of gliprolins in stress-induced alterations. Svit Medycyny Biologii, 2011, 2: 67-71 (Ukrainian).

Dzhura O, Yashchenko A, Antonyuk V, Lutsyk A. Lectin receptor sites during postnatal osteogenesis in guinea pigs. Advances Clinical Experimental Medicine, 2012, 21(1): 19-26.

Shkandina TI, Dzhura OR, Overchuk MO, Magorivska IB, Stolyar GL, Antonyuk VO, Stoika RS, Lutsyk AD, Bilyy RO. Investigation of tracheal cells glycopeptides using 8 sialospecific lectins. Acta Medica Leopoliensia, 2012, 18(1): 59-65 (Ukrainian).

Varyvoda OYu, Filiak EZ, Lutsyk AD, Stoika RS. Mice lacking pituitary tumor transforming gene show elevated exposure of DGalNAc carbohydrate determinants. Biopolymers and Cell, 2012, 28 (2): 129- 133 (Ukrainian).

https://doi.org/10.7124/bc.00003F

Yashchenko AM, Pankevych LV, Lutsyk AD. Rat liver carbohydrate alterations in streptozotocin-induced diabetic rat. Eur J Anat. 2012, 16(2): 82-90.

Lutsyk AD, Sogomonian Structural, functional, and lectin histochemical characteristics of rat ovaries and endometrium in experimental hyper- and hypothyroidism. Folia Histochem Cytobiol. 2012, 50(3): 331-339.

https://doi.org/10.5603/FHC.2012.0045

Hrycevych NN, Zayachkivska OS, Yashchenko AM, Gzhegotsky MR, Lutsyk AD. The search for new markers of endothelial disfunction in non-erosive esophagitis under postprandial hyperglycemia and effect of L-tryptophan. Practychna Medycyna, 2012, 18(5): 29-38 (Ukrainian).

Chetverikov SG, Yashchenko AM, Yeryomin YuV, Volodyuk Morphological diagnosis of connective tissue dysplasia in patients with postoperative abdominal hernia. Klinichna Chirurgiia, 2012, 5: 19-23 (Ukrainian).

Lutsyk A, Ambarova N, Antonyuk Diabetic alteration versus postnatal maturation of rat kidney glycoconjugates: comparative detection by lectin probes. Folia Histochem Cytobiol. 2013, 51(1): 92-102.

https://doi.org/10.5603/FHC.2013.0013

Strus Kh, Yashchenko A, Smolkova O, Nakonechna Influence of maternal experimental hypothyroidism on quantitative-qualitative indicators of rat progeny skin mast cells in age-related aspect according to the results of histochemical investigation and on the base of lectins GNA and PNA receptors cytotopography. Advances Bioscience Biotechnology, 2013, 4: 840-845.

https://doi.org/10.4236/abb.2013.48111

Hrycevych N, Zayachkivska O, Yashchenko Postprandial hyperglycemia changed fucosylated pattern of the oesophageal epithelial barrier activity through the nitrogen oxide mechanism. Current Issues Pharmacy Medical Sciences, 2013, 26(1): 94-98.

Varyvoda OYu, Yashchenko AM, Lutsyk AD, Bilyy RO, Afanasiev SV, Filiak YeZ, Stoika RS. Mice with pituitary tumor transforming gene (pttg) knockout demonstrate increased urinary space in renal corpuscles. Biopolymers and Cell 2014, 30(2): 122-128.

https://doi.org/10.7124/bc.00088A

Yashchenko AM, Lutsyk SA, Renka DJ, Bilyy RO, Lutsyk Alterations of carbohydrate deterninants in rat adrenal gland following experimental hypothyroidism. Eur J Anat. 2014, 18(2): 75-80.

Antonyuk R, Lutsyk A, Antonyuk Lectin purification from fruiting bodies of brown roll-rim fungus, Paxillus involutus(Fr.) Fr., and its application in histochemistry. Rom J Morphol Embryol. 2014, 55(3): 787-796.

Zastavnyy II, Yashchenko AM, Lutsyk AD. Carbohydrate determinants of chorionic villi of human embryos, died as a result of sporadic and recurrent pregnancy Lvivskii Klinichnyi Bulleten, 2014, 4(8): 24-29 (Ukrainian).

Zastavnyy I, Yashchenko A, Lutsyk A, Tkach I. Chorionic villi of human embryos, died out of sporadic and recurrent miscarriages: a lectin histochemitry Svit Medytsyny Biologii, 2015, 1(48): 126- 132 (Ukrainian).

Antonyuk R, Lutsyk A, Antonyuk Colon tumor markers and their medical significance: carbohydrate receptors, sialylation value, detection and therapy based on selective recognition of lectin receptors. Lambert Academic Publishing, 2015.

Antonyuk RV, Lutsyk AD. Lectin histochemical investigation of human colon in normal and neoplastic conditions using lectins specific for T-antigen and N-acetyl-lactosamine. Svit Medytsyny Biologii, 2015, 2(49): 73-78 (Ukrainian).

Dudok OV, Lutsyk AD. Histo- and cytoarchitectonics of spleen under use of antihistamines. Svit Medyt- syny Biologii, 2015, 4(54): 120-123 (Ukrainian).

Antoniuk RV, Lutsyk AD. Lectin histochemistry of the gut of the representatives of different classes vertebrates. Morphology, 2015, 9(4): 7-20 (Ukrainian).

Dudok OV, Yashchenko AM, Lutsyk AD. Morphological and lectin histochemical characteristics of the spleen under experimental administration of H1-histamine receptor Morphology, 2016, 10(1): 32-37 (Ukrainian).

Dudok O, Lutsyk A. Structural and lectin-detectable changes in liver induced by a long-term administration of an anti-histamine drug Loratadine. Journal Medical Science, 2016, 85(2): 114-121.

https://doi.org/10.20883/jms.2016.113

Antonyuk RV, Lutsyk AD, Antonyuk Purification of lectin from the eggs of carp (Cyprinus carpio L.): investigation of its carbohydrate specificity and application for histochemical research. Rom J Morphol Embryol. 2016, 57(3): 985-994.

Yashchenko A, Zastavnyy I, Smolkova O, Strus K, Pankevych Morphological and lectin histochemical features of white nonlinear rats myocardium during experimental hypothyroidism. Journal Advances Biology, 2016, 9(2): 1866-1871.

Yashchenko A, Pankevych L, Smolkova O, Strus K, Zastavnyy I, Lutsyk A. Glycoconjugates of rat lung structural components in experimental hypothyroidism according to lectin histochemistry data. International Journal Advanced Research, 2016, 4(9): 1993-2000.

https://doi.org/10.21474/IJAR01/1683

Shchur MB, Strus KI, Smolkova OV, Yashchenko AM, Lutsyk AD. Glycoconjugates of the rat eyeball structural components under experimental hypothyroidism according to lectin histochemistry studies. Cell Biology Research Therapy, 2017, 6(1): 129-135.

Ivankevych RY, Yashchenko AM, Lutsyk AD. Maternal hypothyroidism induces an elevated exposure of DGal andDGalNAc carbohydrate determinants in gastric gland glycoconjugates of the offspring rats. Bulleten Problem Biologii Medytsyny, 2017, 2(136): 294-298 (Ukrainian).

Shegedin AY, Yashchenko AM, Lutsyk AD. Exposure of glycoconjugates in postnatal morphogenesis of rat testicle according to PAS-reaction and lectin histochemistry investigation. Svit Medytsyny Biologii, 2017, 2(60): 174-178 (Ukrainian).

Zastavnyy I, Yashchenko Can toluidine blue and lectins become new histochemical markers for early recurrent pregnancy miscarriage? Cell Biology Research Therapy, 2017; 6:1.

https://doi.org/10.4172/2324-9293.1000128

Nytch YA, Yashchenko AM, Lutsyk AD. Exposure of lectin receptors in the structural components of the tongue of offspring rats, which developed under mercasolil-induced hypothyroidism of maternal organism. Bulleten Problem Biologii Medytsyny, 2017, 2(138): 80-87 (Ukrainian).

Shegedin A, Yashchenko A, Lutsyk Modification of rat testicular carbohydrate determinants in postnatal morphogenesis as detected by lectin probes. Journal Cell Science Therapy, 2017, 8(4): 274-282.

https://doi.org/10.4172/2157-7013.1000274

Shegedin A, Yashchenko A, Lutsyk Influence of maternal hypothyroidism on postnatal development of rat testicles as detected by morphometric and lectin histochemistry analysis. Acta Medica Leopoliensia, 2017, 23(3): 80-88.

Bilyy RO, Stoika RS. Lectinocytochemical detection of apoptotic murine leukemia L1210 cells. Cytome- try A, 2003, 56(1): 89-95.

https://doi.org/10.1002/cyto.a.10089

Bilyy RO, Antonyyk VO, Stoika Cytochemical study of role of alpha-D-mannose- and beta-D-galac- tose-containing glycoproteins in apoptosis. J Mol Histol. 2004, 35: 829-838.

https://doi.org/10.1007/s10735-004-1674-z

Bilyy R, Kit Y, Hellman U, Tryndyak V, Kaminskyy V, Stoika R. In vivo expression and characteristics of novel alpha-D-mannose-rich glycoprotein markers of apoptotic Cell Biol Int. 2005, 29: 920-928.

https://doi.org/10.1016/j.cellbi.2005.08.003

Bilyy R, Stoika Search for novel cell surface markers of apoptotic cells. Autoimmunity, 2007, 40: 249-253.

https://doi.org/10.1080/08916930701358867

Meesmann HM, Fehr EM, Kierschke S, Herrmann M, Bilyy R, Heyder P, Blank N, Krienke S, Lorenz HM, Schiller M. Decrease of sialic acid residues as an eat-me signal on the surface of apoptootic lympho- cytes. J Cell Sciences, 2010, 123: 3347-3356.

https://doi.org/10.1242/jcs.066696

Shkandina T, Herrmann M, Bilyy R. Sweet kiss of dying cell: sialidase activity on apoptotic cell is adlle to act toward its neighbors. Autoimmunity, 45: 574-578.

https://doi.org/10.3109/08916934.2012.719951

Heyder P, Gaipl US, Beyer TD, Voll RE, Kern PM, Stach C, Kalden JR, Herrmann M. Early detection of apoptosis by staining of acid-treated apoptotic cells with FITZ-labeled lectin from Narcissus pseudonarcissus. Cytometry A, 2003, 55(2): 86-93.

https://doi.org/10.1002/cyto.a.10078

Bilyy RO, Shkandina T, Tomin A, Munos LE, Franz S, Antonyuk V, Kit YY, Zirngibl M, Furnrohr BG, Janko C, Lauber K, Schiller M, Schett G, Stoika RS, Herrmann Macrophages discriminate glycosilation patterns of apoptotic cell-derived microparticles. J Biological Chemistry, 2012, 287: 496-503.

https://doi.org/10.1074/jbc.M111.273144

Brument S, Sivignon A, Dumych TI, Moreau N, Roos G, Guerardel Y, Chalopin T, Deniaud D, Bilyy RO, Darfeuille-Michaud A, Bouckaert J, Gouin SG. Thiazolylaminomannosides as potent antiadhesives of type Ipiliated Escherichia coli isolated from Crohn’s disease J Medicinal Chemistry, 2013, 56: 5395-5406.

https://doi.org/10.1021/jm400723n

Dumych T, Lutsik M, Banski M, Yashchenko A, Sojka B, Horbay R, Lutsyk A, Stoika R, Misiewicz J, Pod- horodecki A, Bilyy Visualization of melanoma tumor with lectin-conjugated rare-earth doped fluoride nanocrystals. Croat Med J. 2014, 55(3): 186-194.

https://doi.org/10.3325/cmj.2014.55.186

Shauer C, Janko C, Munoz LE, Zhao Y, Kienhofer D, Frey B, Lell M, Manger B, Rech J, Naschberger E, Holmdahl R, Krenn V, Harrer T, Jeremic I, Bilyy R, Schett G, Hoffmann M, Herrmann Aggregated neu- trophil extracellular traps limit inflammation by degrading cytokines and chemokines. Nature Medicine, 2014, 20(5): 511-517.

https://doi.org/10.1038/nm.3547

Bilyy R, Podhorodecki A. Can we use rare-earth nanocrystals to target glycans for the visualization of melanoma? Nanomedicine, 2015, 10(13): 1997-2000.

https://doi.org/10.2217/nnm.15.78

Tomin A, Dumych T, Tolstyak Y, Kril I, Mahorivska I, Bila E, Stoika R, Herrmann M, Kit Y, Bilyy R. Desi- alylation of dying cells with catalytically active antibodies possessing sialidase activity facilitates their clearance by human macrophages. Clin Exp Immunol. 2015, 179(1): 17-23.

https://doi.org/10.1111/cei.12312

Kit Y, Bilyy R, Korniy N, Tomin A, Chopyak V, Tolstyak Y, Antonyuk V, Stoika Two-step chromatography purification of IgGs possessing sialidase activity from human blood serum. Biomed Chromatogr. 2015, 29(3): 328-332.

https://doi.org/10.1002/bmc.3283

Munoz LE, Bilyy R, Biermann MH, Kienhofer D, Maueroder C, Hahn J, Brauner JM, Weidner D, Chen J, Scharin-Mehlmann M, Janko C, Friedrich RP, Mielenz D, Dumych T, Lootsik MD, Schauer C, Schett G, Hoffmann M, Zhao Y, Herrmann M. Nanoparticles size-dependently initiate self-limiting NETosis-driven inflammation. Proc Natl Acad Sci USA. 2016, 113(40): E5856-E5865.

https://doi.org/10.1073/pnas.1602230113

Bilyy, Fedorov V., Vovk V., Leppkes M, Dumych T, Chopyak V, Schett G, Herrmann M. Neutrophil extracellular traps form a barrier between necrotic and viable areas in acute abdominal inflammation. Front Immunol. 2016, 7: 424.

https://doi.org/10.3389/fimmu.2016.00424

Biermann MH, Griffante G, Podolska MJ, Boeltz S, Stürmer J, Munoz LE, Bilyy R, Herrmann M. Sweet but dangerous – the role of immunoglobulin G glycosylation in autoimmunity and Lupus, 2016, 25(8): 934-942.

Chalopin T, Alvarez Dorta D, Sivignon A, Caudan M, Dumych TI, Bilyy RO, Deniaud D, Barnich N, Bouc- kaert J, Gouin SG. Second generation of thiazolylmannosides, FimH antagonists for E. coli-induced Crohn’s disease. Org Biomol Chem. 2016, 14(16): 3913-3925.

https://doi.org/10.1039/C6OB00424E

Alvarez Dorta D, Sivignon A, Chalopin T, Dumych TI, Roos G, Bilyy RO, Deniaud D, Krammer EM, de Ruyck J, Lensink MF, Bouckaert J, Barnich N, Gouin SG. The antiadhesive strategy in Crohn’s disease: orally active mannosides to decolonize pathogenic Escherichia coli from the Chem Biochem. 2016, 17(10): 936-952.

Maueroder C, Chaurio R, Dumych T, Podolska M, Lootsik MD, Culemann S, Friedrich R, Bilyy R, Alexiou C, Schett G, Berens C, Herrmann M, Munoz LE. A blast without power – cell death induced by the Tu- berculosis-Necrotizing Toxin (TNT) fails to elicit adequate immune Cell Death Differentiation, 2016, 23(6): 1016-1025.

https://doi.org/10.1038/cdd.2016.4

Magorivska I, Munoz LE, Janko C, Dumych T, Rech J, Schett G, Nimmerjahn F, Bilyy R, Herrmann Si- alylation of anti-histone IgG autoantibodies determines their capabilities to participate in the clearance of late apoptotic cells. Clin Exp Immunol. 2016. doi: 10.1111/cei.12744.

https://doi.org/10.1111/cei.12744

Sojka B, Podhorodecki A, Banski M, Misiewicz J, Drobczynski S, Dumych T, Lutsik MM, Lutsyk A, Bilyy R. β-NaGdF 4: Eu 3+ nanocrystal markers for melanoma tumor imaging. RSC Advances, 2016, 6(63): 57854-57862.

https://doi.org/10.1039/C6RA10351K

Stumer J, Biermann MHC, Knopf J, Magorivska I, Kastbom A, Svard A, Janko C, Bilyy R, Schett G, Sjowall C, Herrmann M, Munoz LE. Altered glycan accessibility on native immunoglobulin G complexes in early rheumatoid arthritis and its changes during Clin Exp Immunol. 2017, 189(3): 372-382.

https://doi.org/10.1111/cei.12987

Alvarez Dorta D, Chalopin T, Sivignon A, de Ruyck J, Dumych TI, Bilyy RO, Deniaud D, Barnich N, Bouckaert J, Gouin SG. Physicochemical tuning of potent Escherichia coli anti-adhesives by microencapsulation and methylene homologation. Chem Med Chem. 2017, 12(12): 986-998.

https://doi.org/10.1002/cmdc.201700061


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Published
2017-12-20
How to Cite
1.
Lutsyk A, Yashchenko A, Antonyuk V, Bilyy R. FUNDAMENTAL AND APPLIED LECTINOLOGY: CONTRIBUTION OF LVIV SCIENTISTS (1972-2017) DEDICATED TO 75TH BIRTH ANNIVERSARY OF MAXYM D. LUTSIK – LVIV LECTINOLOGISTS TEAM FOUNDER. Proc Shevchenko Sci Soc Med Sci [Internet]. 2017Dec.20 [cited 2022Jul.2];50(2):10-2. Available from: https://mspsss.org.ua/index.php/journal/article/view/102